Monocyte counts and prostate cancer outcomes in white and black men: results from the SEARCH database.
Monocyte counts and prostate cancer outcomes in white and black men: results from the SEARCH database.
复制标题
白人和黑人的单核细胞计数和前列腺癌的结果：搜索数据库的结果。
DOI：
10.1007/s10552-020-01373-2
复制
发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Vidal AC
中科院分区：
文献类型：
--
作者：
Yirga A;Oyekunle T;Howard LE;De Hoedt AM;Cooperberg MR;Kane CJ;Aronson WJ;Terris MK;Amling CL;Taioli E;Fowke JH;Klaanssen Z;Freedland SJ;Vidal AC
循环炎症标志物可以预测前列腺癌（PC）的结果。例如，最近的一项研究表明，较高的外周血单核细胞计数与接受根治性前列腺切除术（RP）的亚洲男性的侵袭性PC相关。在此，我们研究了外周血单核细胞计数是否可以预测黑人和白色男性RP后的长期PC结局。我们回顾性分析了2000年至2017年在8家退伍军人事务部医院接受RP的2，345名男性的数据。收集术前6个月和12个月内单核细胞计数的数据。研究结果包括生化复发（BCR）、去势抵抗性PC（CRPC）、转移、全因死亡率（ACM）和PC特异性死亡率（PCSM）。使用Cox比例风险模型来评估术前单核细胞计数与上述结果（考虑混杂因素）之间的相关性。在2,345名RP患者中，972名（41%）为黑人，1,373名（59%）为白色男性。在多变量分析中，我们发现单核细胞计数和BCR在所有男性中（HR：1.36，95%CI 0.90-2.07）或按种族分层分析时（HR：1.30，95%CI 0.69-2.46，黑人男性; HR：1.33，95%CI 0.76-02.33，白色男性）没有相关性。同样，未发现单核细胞计数与CRPC、转移、ACM和PCSM之间存在总体或人种特异性相关性，所有p均≥0.15。RP前12个月测量的单核细胞计数结果相似。在接受RP的黑人和白色PC患者中，外周血单核细胞计数与长期PC结局无关。与亚洲人群中的结果相反，本研究中单核细胞计数与PC结局无关。
Circulating inflammatory markers may predict prostate cancer (PC) outcomes. For example, a recent study showed that higher peripheral blood monocyte counts were associated with aggressive PC in Asian men undergoing radical prostatectomy (RP). Herein, we investigated whether peripheral monocyte count can predict long-term PC outcomes after RP in black and white men. We retrospectively reviewed data on 2,345 men undergoing RP from 2000 to 2017 at eight Veterans Affairs hospitals. Data on monocyte count within 6 and 12 months prior to surgery were collected. The study outcomes were biochemical recurrence (BCR), castration-resistant PC (CRPC), metastasis, all-cause mortality (ACM), and PC-specific morality (PCSM). Cox-proportional hazard models were used to assess the associations between pre-operative monocyte count and the above-mentioned outcomes accounting for confounders. Of 2,345 RP patients, 972 (41%) were black and 1,373 (59%) were white men. In multivariable analyses, we found no associations between monocyte count and BCR among all men (HR:1.36, 95%CI 0.90–2.07) or when analyses were stratified by race (HR:1.30, 95%CI 0.69–2.46, in black men; HR:1.33, 95%CI 0.76–02.33, in white men). Likewise, no overall or race-specific associations were found between monocyte count and CRPC, metastases, ACM, and PCSM, all p≥0.15. Results were similar for monocyte count measured at 12 months prior to RP. In black and white PC patients undergoing RP, peripheral monocyte count was not associated with long-term PC outcomes. Contrary to what was found in Asian populations, monocyte count was not associated with PC outcomes in this study.
登录
查看更多内容
DOI：
10.1158/1078-0432.ccr-14-2235
发表时间：
2015-02-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Vidal AC;Howard LE;Moreira DM;Castro-Santamaria R;Andriole GL;Freedland SJ
通讯作者：
Freedland SJ
影响因子：
--
作者：
Hayashi T;Fujita K;Tanigawa G;Kawashima A;Nagahara A;Ujike T;Uemura M;Takao T;Yamaguchi S;Nonomura N
通讯作者：
Nonomura N
影响因子：
11.1
作者：
Yang J;Zhang L;Yu C;Yang XF;Wang H
通讯作者：
Wang H
影响因子：
3
作者：
Yuri, Prahara;Shigemura, Katsumi;Fujisawa, Masato
通讯作者：
Fujisawa, Masato
影响因子：
2.8
作者：
Hayashi, Takuji;Fujita, Kazutoshi;Nonomura, Norio
通讯作者：
Nonomura, Norio