Dietary docosahexaenoic and eicosapentaenoic acid: emerging mediators of inflammation.
Dietary docosahexaenoic and eicosapentaenoic acid: emerging mediators of inflammation.
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DOI：
10.1016/j.plefa.2009.05.010
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发表时间：
2009-08
期刊：
影响因子：
--
通讯作者：
McMurray DN
中科院分区：
文献类型：
--
作者：
Chapkin RS;Kim W;Lupton JR;McMurray DN
炎症反应旨在帮助对抗和清除感染，清除有害化学物质，修复受损的组织和器官系统。虽然这一过程通常具有保护作用，但如果不能消除炎症并使目标组织恢复稳态，则可能导致疾病，包括促进癌症的发生。大量已发表的文献支持膳食n-3多不饱和脂肪酸（PUFA），特别是二十碳五烯酸（EPA, 20:5n-3）和二十二碳六烯酸（DHA, 22:6n-3）是宿主炎症/免疫反应的重要调节剂的观点。下面的综述描述了一个机制模型，可以部分解释EPA和DHA的多效抗炎和免疫抑制特性。在这篇综述中，我们将重点关注n-3 PUFA作用的三个主要机制的重要研究：(i)核受体激活的调节，即核因子-κB （NF-κB）的抑制；（ii）花生四烯酸-环氧合酶衍生的二十烷类化合物，主要是前列腺素e2依赖性信号的抑制；（iii）质膜微组织（脂筏）的改变，特别是因为它与toll样受体（TLRs）的功能和t淋巴细胞信号分子募集到免疫突触（IS）有关。我们认为脂筏可能是开发含n-3 pufa的膳食生物活性药物的目标，以降低炎症和免疫反应，并用于治疗自身免疫性和慢性炎症性疾病。
The inflammatory response is designed to help fight and clear infection, remove harmful chemicals, and repair damaged tissue and organ systems. Although this process, in general, is protective, the failure to resolve the inflammation and return the target tissue to homeostasis can result in disease, including the promotion of cancer. A plethora of published literature supports the contention that dietary n-3 polyunsaturated fatty acids (PUFA), and eicosapentaenoic (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3) in particular, are important modulators of a host's inflammatory/immune responses. The following review describes a mechanistic model that may explain, in part, the pleiotropic anti-inflammatory and immunosuppressive properties of EPA and DHA. In this review, we focus on salient studies that address three overarching mechanisms of n-3 PUFA action: (i) modulation of nuclear receptor activation, i.e., nuclear factor-κB (NF-κB) suppression; (ii) suppression of arachidonic acid–cyclooxygenase-derived eicosanoids, primarily prostaglandin E2-dependent signaling; and (iii) alteration of the plasma membrane micro-organization (lipid rafts), particularly as it relates to the function of Toll-like receptors (TLRs), and T-lymphocyte signaling molecule recruitment to the immunological synapse (IS). We propose that lipid rafts may be targets for the development of n-3 PUFA-containing dietary bioactive agents to down-modulate inflammatory and immune responses and for the treatment of autoimmune and chronic inflammatory diseases.
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DOI：
10.1084/jem.20050222
发表时间：
2005-03-07
期刊：
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影响因子：
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发表时间：
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影响因子：
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