Clinical translation of an ultrasmall inorganic optical-PET imaging nanoparticle probe.
Clinical translation of an ultrasmall inorganic optical-PET imaging nanoparticle probe.
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超大无机光PET成像纳米粒子探针的临床翻译。
DOI：
10.1126/scitranslmed.3009524
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发表时间：
2014-10-29
影响因子：
17.1
通讯作者：
Bradbury MS
中科院分区：
文献类型：
--
作者：
Phillips E;Penate-Medina O;Zanzonico PB;Carvajal RD;Mohan P;Ye Y;Humm J;Gönen M;Kalaigian H;Schöder H;Strauss HW;Larson SM;Wiesner U;Bradbury MS
超小无机混合纳米颗粒“C点”（康奈尔点）在转移性黑色素瘤患者中的首次人体临床试验被描述用于癌症成像。这些肾排泄的二氧化硅颗粒用124 I标记用于正电子发射断层扫描（PET）成像，并用cRGDY肽修饰用于分子靶向。124 I-cRGDY-PEG-C点颗粒本身具有荧光性，含有染料Cy 5，因此它们可用作混合PET-光学成像剂，用于人类的病变检测、癌症分期和治疗管理。然而，包括量子点在内的纳米粒子探针的临床转化并没有跟上依赖于光学成像剂的微创手术工具的加速增长。在患者静脉给药后，通过连续PET和计算机断层扫描评估124 I-cRGDY-PEG-C点的安全性、药代动力学、清除特性和辐射剂量测定。在2周的时间间隔内监测颗粒注射前后获得的血液和尿液标本的代谢特征和实验室检查。结果与耐受性良好的无机颗粒示踪剂一致，表现出体内稳定性和由肾排泄定义的独特、可重现的药代动力学特征。未观察到可归因于颗粒的毒性或不良事件。再加上优先摄取和定位的探针在疾病部位，这些首次在人类的结果表明，安全使用这些粒子在人类癌症诊断。
A first-in-human clinical trial of ultrasmall inorganic hybrid nanoparticles, “C dots” (Cornell dots), in patients with metastatic melanoma is described for the imaging of cancer. These renally excreted silica particles were labeled with 124I for positron emission tomography (PET) imaging and modified with cRGDY peptides for molecular targeting. 124I-cRGDY–PEG–C dot particles are inherently fluorescent, containing the dye, Cy5, so they may be used as hybrid PET-optical imaging agents for lesion detection, cancer staging, and treatment management in humans. However, the clinical translation of nanoparticle probes, including quantum dots, has not kept pace with the accelerated growth in minimally invasive surgical tools that rely on optical imaging agents. The safety, pharmacokinetics, clearance properties, and radiation dosimetry of 124I-cRGDY–PEG–C dots were assessed by serial PET and computerized tomography after intravenous administration in patients. Metabolic profiles and laboratory tests of blood and urine specimens, obtained before and after particle injection, were monitored over a 2-week interval. Findings are consistent with a well-tolerated inorganic particle tracer exhibiting in vivo stability and distinct, reproducible pharmacokinetic signatures defined by renal excretion. No toxic or adverse events attributable to the particles were observed. Coupled with preferential uptake and localization of the probe at sites of disease, these first-in-human results suggest safe use of these particles in human cancer diagnostics.
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临床翻译的二氧化硅纳米颗粒作为以癌为标志性的探针进行图像引导的手术和干预措施。
DOI：
10.1039/c2ib20174g
发表时间：
2013-01
期刊：
Integrative biology : quantitative biosciences from nano to macro
影响因子：
--
作者：
Bradbury MS;Phillips E;Montero PH;Cheal SM;Stambuk H;Durack JC;Sofocleous CT;Meester RJ;Wiesner U;Patel S
通讯作者：
Patel S
影响因子：
10.8
作者：
Burns AA;Vider J;Ow H;Herz E;Penate-Medina O;Baumgart M;Larson SM;Wiesner U;Bradbury M
通讯作者：
Bradbury M
在分化甲状腺癌患者中，124i-PET的诊断值。
DOI：
10.1007/s00259-007-0660-6
发表时间：
2008-05
影响因子：
9.1
作者：
Phan, Ha T. T.;Jager, Pieter L.;Paans, Anne M. J.;Plukker, John T. M.;Sturkenboom, M. G. G.;Sluiter, W. J.;Wolffenbuttel, Bruce H. R.;Dierckx, Rudi A. J. O.;Links, Thera P.
通讯作者：
Links, Thera P.
影响因子：
15.8
作者：
Haubner R;Weber WA;Beer AJ;Vabuliene E;Reim D;Sarbia M;Becker KF;Goebel M;Hein R;Wester HJ;Kessler H;Schwaiger M
通讯作者：
Schwaiger M
影响因子：
10.8
作者：
Ow, H;Larson, DR;Wiesner, U
通讯作者：
Wiesner, U