Magnetorelaxometry assisting biomedical applications of magnetic nanoparticles.
Magnetorelaxometry assisting biomedical applications of magnetic nanoparticles.
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DOI：
10.1007/s11095-011-0630-3
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发表时间：
2012-05
影响因子：
3.7
通讯作者：
Trahms, Lutz
中科院分区：
文献类型：
--
作者：
Wiekhorst, Frank;Steinhoff, Uwe;Eberbeck, Dietmar;Trahms, Lutz
关键词：
由于其生物相容性和小尺寸，氧化铁磁性纳米颗粒（MNP）可以被引导到几乎所有的生物环境中。MNP易受外部磁场影响，因此可用于药物和基因的运输，用于磁热疗的产热或用于生物组织磁共振成像的对比度增强。同时，它们的磁性使人们能够开发出敏感和特定的测量方法来非侵入性地检测MNP，量化MNP在组织中的分布并确定它们的结合状态。本文综述了磁松弛法（MRX）在MNP检测中的应用。描述了产生MRX信号的MNP的基本物理性质及其弛豫幅度和弛豫时间的特征参数。回顾了现有的单通道和多通道MRX设备。最后，我们详细描述了MRX在细胞MNP定量、MNP器官分布和基于MNP的结合分析中的一些应用。提供特定的MNP信号，检测限低至几纳克的MNP，在有意识的动物体内的能力和几秒钟的测量时间，MRX是提高MNP在诊断和治疗目的应用的有价值的工具。
Due to their biocompatibility and small size, iron oxide magnetic nanoparticles (MNP) can be guided to virtually every biological environment. MNP are susceptible to external magnetic fields and can thus be used for transport of drugs and genes, for heat generation in magnetic hyperthermia or for contrast enhancement in magnetic resonance imaging of biological tissue. At the same time, their magnetic properties allow one to develop sensitive and specific measurement methods to non-invasively detect MNP, to quantify MNP distribution in tissue and to determine their binding state. In this article, we review the application of magnetorelaxometry (MRX) for MNP detection. The underlying physical properties of MNP responsible for the generation of the MRX signal with its characteristic parameters of relaxation amplitude and relaxation time are described. Existing single and multi-channel MRX devices are reviewed. Finally, we thoroughly describe some applications of MRX to cellular MNP quantification, MNP organ distribution and MNP-based binding assays. Providing specific MNP signals, a detection limit down to a few nanogram MNP, in-vivo capability in conscious animals and measurement times of a few seconds, MRX is a valuable tool to improve the application of MNP for diagnostic and therapeutic purposes.
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影响因子：
2.1
作者：
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通讯作者：
Krishnan KM
影响因子：
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作者：
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通讯作者：
Haueisen, Jens
影响因子：
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作者：
Eberbeck, D;Bergemann, C;Trahms, L
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Trahms, L
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作者：
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