Perspectives on Existing and Novel Alternative Intravaginal Probiotic Delivery Methods in the Context of Bacterial Vaginosis Infection.
Perspectives on Existing and Novel Alternative Intravaginal Probiotic Delivery Methods in the Context of Bacterial Vaginosis Infection.
复制标题
细菌性阴道病感染背景下现有和新型替代阴道内益生菌给药方法的观点。
DOI：
10.1208/s12248-021-00602-z
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发表时间：
2021-05-10
期刊：
影响因子：
--
通讯作者：
Steinbach-Rankins JM
中科院分区：
文献类型：
--
作者：
Chandrashekhar P;Minooei F;Arreguin W;Masigol M;Steinbach-Rankins JM
细菌性阴道病（BV）是最常见的阴道感染之一，影响全球数亿育龄妇女。传统的治疗策略，如口服和局部抗生素，已显示出对BV的疗效，但感染的频繁复发和耐药细菌的发展仍然是重大挑战。或者，最近在了解阴道微生物群中的免疫、微生物和代谢相互作用方面的进展促使人们考虑在BV预防和治疗的背景下施用益生菌以恢复和维持阴道健康。鉴于此，本综述的目的是讨论现有的和潜在的替代方法来提供，并可能维持益生菌的交付，以预防和/或治疗BV感染。首先，简要概述了益生菌种类和组合益生菌策略，这些策略在治疗BV和恢复女性生殖健康方面表现出了希望。此外，讨论了与当前口服和阴道内益生菌递送平台相关的优点和挑战。最后，我们提出了新兴的和有前途的替代剂型，如电纺纤维和3D生物打印支架，这些剂型可能适合作为阴道内递送益生菌的新策略。
Bacterial vaginosis (BV) is one of the most common vaginal infections that affects hundreds of millions of women of reproductive age, worldwide. Traditional treatment strategies, such as oral and topical antibiotics, have shown efficacy against BV, but frequent recurrence of infection and the development of antibiotic-resistant bacteria remain as significant challenges. Alternatively, recent progress in understanding immune, microbiological, and metabolic interactions in the vaginal microbiota has prompted the consideration of administering probiotic organisms to restore and maintain vaginal health within the context of BV prevention and treatment. Given this, the objective of this review is to discuss existing and potential alternative approaches to deliver, and to potentially sustain the delivery of probiotics, to prevent and/or treat BV infections. First, a brief overview is provided regarding the probiotic species and combinatorial probiotic strategies that have shown promise in the treatment of BV and in restoring female reproductive health. Additionally, the advantages and challenges associated with current oral and intravaginal probiotic delivery platforms are discussed. Lastly, we present emerging and promising alternative dosage forms, such as electrospun fibers and 3D bioprinted scaffolds, that may be adapted as new strategies to intravaginally deliver probiotic organisms.
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发表时间：
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