Relationships between mechanical properties and drug release from electrospun fibers of PCL and PLGA blends.
Relationships between mechanical properties and drug release from electrospun fibers of PCL and PLGA blends.
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DOI：
10.1016/j.jmbbm.2016.09.004
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发表时间：
2017-01
影响因子：
3.9
通讯作者：
Woodrow KA
中科院分区：
文献类型：
--
作者：
Chou SF;Woodrow KA
电纺纳米纤维具有实现高载药量和持续药物释放的能力的潜力。药物掺入纤维的机械性能表明药物-聚合物相互作用的重要性。在这项研究中，我们研究了静电纺丝聚己内酯（PCL）和聚（D，L-乳酸-共-乙醇酸）（PLGA）纤维在各种共混比的存在和不存在的小分子亲水性药物，替诺福韦（TFV）的机械性能。共混纤维的杨氏模量与PLGA含量和药物添加量有关。在PCL/PLGA（20/80）组合物中，杨氏模量和拉伸强度与高达40重量%的药物负载无关，这是由于药物-聚合物相互作用的抵消效应。体外药物释放研究表明，TFV的释放显着降低纤维的机械性能。此外，与未拉伸的纤维相比，机械拉伸的纤维显示出更快的释放速率。最后，共混物纤维中的药物分配估计使用的力学模型，然后实验证实与单独堆叠的纤维网的复合材料。这项工作提供了药物释放和载药的药物洗脱纤维的机械性能的依赖性的科学理解。电纺药物洗脱纤维中药物-聚合物相互作用。药物释放、聚合物降解与纤维拉伸性能的相关性。共混聚酯纤维中的药物分配。
Electrospun nanofibers have the potential to achieve high drug loading and the ability to sustain drug release. Mechanical properties of the drug-incorporated fibers suggest the importance of drug–polymer interactions. In this study, we investigated the mechanical properties of electrospun polycaprolactone (PCL) and poly (D,L-lactic-co-glycolic) acid (PLGA) fibers at various blend ratios in the presence and absence of a small molecule hydrophilic drug, tenofovir (TFV). Young׳s modulus of the blend fibers showed dependence on PLGA content and the addition of the drug. At a PCL/PLGA (20/80) composition, Young׳s modulus and tensile strength were independent of drug loading up to 40 wt% due to offsetting effects from drug–polymer interactions. In vitro drug release studies suggested that release of TFV significantly decreased fiber mechanical properties. In addition, mechanically stretched fibers displayed a faster release rate as compared to the non-stretched fibers. Finally, drug partition in the blend fibers was estimated using a mechanical model and then experimentally confirmed with a composite of individually stacked fiber meshes. This work provides scientific understanding on the dependence of drug release and drug loading on the mechanical properties of drug-eluting fibers. Drug–polymer interactions in electrospun drug-eluting fibers. Correlations of drug release, polymer degradation on fiber tensile properties. Drug partitioning in blend polyester fibers.
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DOI：
10.1016/j.jconrel.2015.09.008
发表时间：
2015-12-28
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
Chou SF;Carson D;Woodrow KA
通讯作者：
Woodrow KA
影响因子：
3.3
作者：
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通讯作者：
Rashkov, I.
影响因子：
5.1
作者：
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通讯作者：
Chen, Da-Zhu
影响因子：
9.7
作者：
Li, Wan-Ju;Cooper, James A., Jr.;Tuan, Rocky S.
通讯作者：
Tuan, Rocky S.
影响因子：
5.8
作者：
Mo, Yunfei;Guo, Rui;Zhang, Yuanming
通讯作者：
Zhang, Yuanming