The role of the gut microbiome and diet in the pathogenesis of non-alcoholic fatty liver disease.
The role of the gut microbiome and diet in the pathogenesis of non-alcoholic fatty liver disease.
复制标题
肠道微生物群和饮食在非酒精性脂肪性肝病发病机制中的作用
DOI：
10.3350/cmh.2020.0129
复制
发表时间：
2021-01
影响因子：
8.9
通讯作者：
Byrne CD
中科院分区：
文献类型：
--
作者：
Jennison E;Byrne CD
非酒精性脂肪性肝病（NAFLD）是慢性肝病的主要原因，其患病率随着全球肥胖和2型糖尿病的增加而增加。NAFLD的发病机制复杂、多因素，涉及环境、遗传和代谢等因素。饮食和肠道微生物组的作用作为NAFLD发病机制的一个重要因素正在引起人们的兴趣。饮食因素引起肠道微生物群组成的改变（生态失调），通常反映为有益菌群的减少和致病菌群的增加。由于肠道与肝脏关系密切，改变肠道微生物群会影响肝功能；促进肝脏脂肪变性和炎症。这篇综述总结了目前支持NAFLD与肠道微生物群和饮食因素之间关联的证据。该综述还探讨了支持这些关联的潜在潜在机制，以及操纵肠道微生物组是否是预防或治疗NAFLD的潜在治疗策略。
Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease, with a prevalence that is increasing in parallel with the global rise in obesity and type 2 diabetes mellitus. The pathogenesis of NAFLD is complex and multifactorial, involving environmental, genetic and metabolic factors. The role of the diet and the gut microbiome is gaining interest as a significant factor in NAFLD pathogenesis. Dietary factors induce alterations in the composition of the gut microbiome (dysbiosis), commonly reflected by a reduction of the beneficial species and an increase in pathogenic microbiota. Due to the close relationship between the gut and liver, altering the gut microbiome can affect liver functions; promoting hepatic steatosis and inflammation. This review summarises the current evidence supporting an association between NAFLD and the gut microbiome and dietary factors. The review also explores potential underlying mechanisms underpinning these associations and whether manipulation of the gut microbiome is a potential therapeutic strategy to prevent or treat NAFLD.
登录
查看更多内容
影响因子：
3.7
作者：
Baker SS;Baker RD;Liu W;Nowak NJ;Zhu L
通讯作者：
Zhu L
影响因子：
7.7
作者：
Cani, Patrice D.;Amar, Jacques;Burcelin, Remy
通讯作者：
Burcelin, Remy
影响因子：
2.1
作者：
Asgharian A;Askari G;Esmailzade A;Feizi A;Mohammadi V
通讯作者：
Mohammadi V
影响因子：
4.5
作者：
Cox CL;Stanhope KL;Schwarz JM;Graham JL;Hatcher B;Griffen SC;Bremer AA;Berglund L;McGahan JP;Keim NL;Havel PJ
通讯作者：
Havel PJ
影响因子：
29.4
作者：
Bouter, Kristien E.;van Raalte, Daniel H.;Nieuwdorp, Max
通讯作者：
Nieuwdorp, Max