Virulence-Associated Secretion in Mycobacterium abscessus.
Virulence-Associated Secretion in Mycobacterium abscessus.
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DOI：
10.3389/fimmu.2022.938895
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发表时间：
2022
影响因子：
7.3
通讯作者：
Barkan, Daniel
中科院分区：
文献类型：
--
作者：
Bar-Oz, Michal;Meir, Michal;Barkan, Daniel
非结核分枝杆菌 (NTM) 是一组异质的原始环境生物，越来越多地被认为是病原体，并且在全球范围内患病率不断上升。人们缺乏对 NTM 毒力机制的了解，因为对这些细菌的分子研究具有挑战性，有时比结核分枝杆菌 (Mtb) 的研究更具挑战性，而且分配给其研究的资源要少得多。虽然一些毒力机制是包括 Mtb 在内的几种分枝杆菌所共有的，但其他一些毒力机制是 NTM 物种特异性的。在 NTM 中，脓肿分枝杆菌 (Mab) 会引起一些最严重且最难治疗的感染，尤其是慢性肺部感染。单克隆抗体通过利用多种机制绕过宿主防御而在细胞内存活和增殖，其中许多机制的特征仍不清楚。其中一些免疫逃避机制也存在于结核分枝杆菌中，包括吞噬体孔形成、吞噬体成熟抑制、细胞因子反应干扰和细胞凋亡延迟。虽然人们对 Mtb 分泌的效应分子在介导宿主反应操纵中的作用了解很多，但对 Mab 中分泌的效应分子知之甚少。在这篇综述中，我们简要总结了Mtb中分泌效应器的知识（例如ESX分泌、SecA2、TAT等），并绘制了Mab中的平行通路。我们还描述了 Mab 独特的途径，将其与 Mtb 区分开来。本综述将通过提供知识库和研究框架来帮助对单克隆抗体毒力相关分泌感兴趣的研究人员。
Non-tuberculous mycobacteria (NTM) are a heterogeneous group of originally environmental organi3sms, increasingly recognized as pathogens with rising prevalence worldwide. Knowledge of NTM’s mechanisms of virulence is lacking, as molecular research of these bacteria is challenging, sometimes more than that of M. tuberculosis (Mtb), and far less resources are allocated to their investigation. While some of the virulence mechanisms are common to several mycobacteria including Mtb, others NTM species-specific. Among NTMs, Mycobacterium abscessus (Mabs) causes some of the most severe and difficult to treat infections, especially chronic pulmonary infections. Mabs survives and proliferates intracellularly by circumventing host defenses, using multiple mechanisms, many of which remain poorly characterized. Some of these immune-evasion mechanisms are also found in Mtb, including phagosome pore formation, inhibition of phagosome maturation, cytokine response interference and apoptosis delay. While much is known of the role of Mtb-secreted effector molecules in mediating the manipulation of the host response, far less is known of the secreted effector molecules in Mabs. In this review, we briefly summarize the knowledge of secreted effectors in Mtb (such as ESX secretion, SecA2, TAT and others), and draw the parallel pathways in Mabs. We also describe pathways that are unique to Mabs, differentiating it from Mtb. This review will assist researchers interested in virulence-associated secretion in Mabs by providing the knowledge base and framework for their studies.
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