From mouth to macrophage: mechanisms of innate immune subversion by Mycobacterium avium subsp. paratuberculosis.
From mouth to macrophage: mechanisms of innate immune subversion by Mycobacterium avium subsp. paratuberculosis.
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DOI：
10.1186/1297-9716-45-54
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发表时间：
2014-05-15
影响因子：
4.4
通讯作者：
Napper S
中科院分区：
文献类型：
--
作者：
Arsenault RJ;Maattanen P;Daigle J;Potter A;Griebel P;Napper S
约翰氏病（JD）是一种由鸟分枝杆菌引起的牛的慢性肠道感染。副结核(地图)。JD的高经济成本和潜在的人畜共患威胁促使人们努力开发有效管理畜群中该疾病的工具和方法。通过传统的动物管理实践控制JD的努力由于MAP造成长期环境污染的能力以及在临床前阶段与JD诊断相关的困难而变得复杂。因此，特别强调开发有效的疫苗。这是一项艰巨的挑战，很大程度上是因为MAP具有破坏宿主保护性免疫反应的能力。因此，了解MAP与牛宿主的相互作用是一个优先事项：这可能为治疗干预的合理目标和方法提供信息。在这里，我们回顾了在巨噬细胞摄取和建立持续感染之间的关键时期，MAP遇到的早期宿主防御以及病原体用来避免或破坏这些反应的策略。
Johne’s disease (JD) is a chronic enteric infection of cattle caused by Mycobacterium avium subsp. paratuberculosis (MAP). The high economic cost and potential zoonotic threat of JD have driven efforts to develop tools and approaches to effectively manage this disease within livestock herds. Efforts to control JD through traditional animal management practices are complicated by MAP’s ability to cause long-term environmental contamination as well as difficulties associated with diagnosis of JD in the pre-clinical stages. As such, there is particular emphasis on the development of an effective vaccine. This is a daunting challenge, in large part due to MAP’s ability to subvert protective host immune responses. Accordingly, there is a priority to understand MAP’s interaction with the bovine host: this may inform rational targets and approaches for therapeutic intervention. Here we review the early host defenses encountered by MAP and the strategies employed by the pathogen to avert or subvert these responses, during the critical period between ingestion and the establishment of persistent infection in macrophages.
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DOI：
10.1084/jem.175.4.1111
发表时间：
1992-04-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Chan J;Xing Y;Magliozzo RS;Bloom BR
通讯作者：
Bloom BR
影响因子：
1.3
作者：
Anderson, Jennifer L.;Meece, Jennifer K.;Ellingson, Jay L. E.
通讯作者：
Ellingson, Jay L. E.
影响因子：
--
作者：
Charavaryamath, Chandrashekhar;Gonzalez-Cano, Patricia;Griebel, Philip J.
通讯作者：
Griebel, Philip J.
影响因子：
64.5
作者：
Ferrari, G;Langen, H;Pieters, J
通讯作者：
Pieters, J
影响因子：
3.1
作者：
ADAMS, LB;FUKUTOMI, Y;KRAHENBUHL, JL
通讯作者：
KRAHENBUHL, JL