Detection of resting-state functional connectivity in the lumbar spinal cord with 3T MRI.
Detection of resting-state functional connectivity in the lumbar spinal cord with 3T MRI.
复制标题
检测具有3T MRI的腰椎脊髓中静息状态功能连通性的检测。
DOI：
10.1038/s41598-023-45302-0
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发表时间：
2023-10-24
影响因子：
4.6
通讯作者：
O'Grady, Kristin P.
中科院分区：
文献类型：
--
作者：
Combes, Anna;Narisetti, Lipika;Sengupta, Anirban;Rogers, Baxter P.;Sweeney, Grace;Prock, Logan;Houston, Delaney;McKnight, Colin D.;Gore, John C.;Smith, Seth A.;O'Grady, Kristin P.
脊髓功能性磁共振成像（fMRI）是一个不断扩大的研究领域，具有研究中枢神经系统神经元活动的潜力。我们的目的是使用静息态功能磁共振成像（rs-fMRI）在3 T，使用基于区域和数据驱动的分析方法来表征人类腰髓的功能连接特征。在26名健康受试者中实施了3D多激发梯度回波静息态血氧水平依赖敏感rs-fMRI方案。去噪后灰质的平均时间信噪比为16.35 ± 4.79。使用交互式、探索性的基于种子的相关性，在代表性参与者中观察到腹角和背角与对侧对应物同步信号波动的证据。组间平均切片Pearson相关系数腹角间为0.43 ± 0.17，背角间为0.48 ± 0.16。组空间独立成分分析（伊卡）被用来确定领域的连贯活动的神经元和显示组件内的灰质对应的解剖区域。低维伊卡揭示了对应于腹侧和背侧网络的双边组件。在参与者组的两个子集上运行额外的单独ICA，产生两组显示视觉一致性和适度空间重叠的组件。这项工作表明了rs-fMRI的可行性，探讨功能的特点和组织的腰髓。
Functional MRI (fMRI) of the spinal cord is an expanding area of research with potential to investigate neuronal activity in the central nervous system. We aimed to characterize the functional connectivity features of the human lumbar spinal cord using resting-state fMRI (rs-fMRI) at 3T, using region-based and data-driven analysis approaches. A 3D multi-shot gradient echo resting-state blood oxygenation level dependent-sensitive rs-fMRI protocol was implemented in 26 healthy participants. Average temporal signal-to-noise ratio in the gray matter was 16.35 ± 4.79 after denoising. Evidence of synchronous signal fluctuations in the ventral and dorsal horns with their contralateral counterparts was observed in representative participants using interactive, exploratory seed-based correlations. Group-wise average in-slice Pearson’s correlations were 0.43 ± 0.17 between ventral horns, and 0.48 ± 0.16 between dorsal horns. Group spatial independent component analysis (ICA) was used to identify areas of coherent activity¸ and revealed components within the gray matter corresponding to anatomical regions. Lower-dimensionality ICA revealed bilateral components corresponding to ventral and dorsal networks. Additional separate ICAs were run on two subsets of the participant group, yielding two sets of components that showed visual consistency and moderate spatial overlap. This work shows feasibility of rs-fMRI to probe the functional features and organization of the lumbar spinal cord.
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影响因子：
3.3
作者：
Barry RL;Conrad BN;Maki S;Watchmaker JM;McKeithan LJ;Box BA;Weinberg QR;Smith SA;Gore JC
通讯作者：
Gore JC
用于 fMRI 数据分析的群体信息引导 ICA
影响因子：
5.7
作者：
Du, Yuhui;Fan, Yong
通讯作者：
Fan, Yong
DOI：
10.1212/01.con.0000461082.25876.4a
发表时间：
2015-02-01
期刊：
Continuum (Minneapolis, Minn.)
影响因子：
--
作者：
Cho, Tracey A
通讯作者：
Cho, Tracey A
影响因子：
5.7
作者：
Eippert F;Kong Y;Winkler AM;Andersson JL;Finsterbusch J;Büchel C;Brooks JCW;Tracey I
通讯作者：
Tracey I
影响因子：
5.7
作者：
De Leener, Benjamin;Fonov, Vladimir S.;Cohen-Adad, Julien
通讯作者：
Cohen-Adad, Julien