Recent advances in the use of microfluidic technologies for single cell analysis.

Recent advances in the use of microfluidic technologies for single cell analysis.
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DOI:
10.1039/c7an01346a
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发表时间:
2017-12-18
期刊:
The Analyst
影响因子:
--
通讯作者:
Lu C
Lu C
中科院分区:
其他
文献类型:
--
作者:
Murphy TW;Zhang Q;Naler LB;Ma S;Lu C

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The inherent heterogeneity in cell populations has become of great interest and importance as analytical techniques have improved over the past decades. With the advent of personalized medicine, understanding the impact of this heterogeneity has become an important challenge for the research community. Many different microfluidic approaches with varying levels of throughput and resolution exist to study single cell activity. In this review, we take a wide view of the recent microfluidic developments for single cell analysis based on microwell, microchamber, and droplet platforms. We cover physical, chemical, and molecular biology approaches for cellular and molecular analysis including newly emerging genome-wide analysis. We present a review on recent advances on single cell analysis based on microfluidic platforms.
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