The effects of social contact on cocaine intake in female rats.
The effects of social contact on cocaine intake in female rats.
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DOI：
10.1016/j.drugalcdep.2017.03.027
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发表时间：
2017-08-01
影响因子：
4.2
通讯作者：
Smith MA
中科院分区：
文献类型：
--
作者：
Robinson AM;Fronk GE;Zhang H;Tonidandel S;Smith MA
在雄性大鼠中进行的研究报告说，社会接触可以促进或抑制药物摄入，这取决于社会伙伴的行为。本研究的目的是：（1）研究社会接触对雌性大鼠可卡因摄入的影响，（2）研究社会接触影响可卡因摄入的行为机制，（3）研究发情周期是否调节社会接触对可卡因摄入的影响。将雌性大鼠分配到隔离或成对饲养的条件下，其中社会伴侣可以获得可卡因（可卡因伴侣）或无法获得可卡因（禁欲伴侣）。在定制的操作性条件处理室中对成对饲养的大鼠进行测试，该操作性条件处理室允许两只大鼠在同一室中同时进行测试。与可卡因伴侣关在一起的大鼠比单独的大鼠和与禁欲伴侣关在一起的大鼠自我注射更多的可卡因。一项行为经济学分析表明，这些差异是由可卡因需求的更大强度驱动的（即，更大的摄入量在较低的单位价格）与可卡因的合作伙伴圈养的大鼠。多变量模型显示，动情周期并没有缓和社会接触对可卡因摄入量的影响。这些调查结果表明：（1）社会接触影响可卡因自我管理在女性中的方式类似于在男性中报告的，（2）这些影响是由于社会接触对可卡因需求强度的影响的差异，（3）这些影响在发情周期的所有阶段都是一致的。
Studies conducted in male rats report that social contact can either facilitate or inhibit drug intake depending on the behavior of social partners. The purpose of the present study was to: (1) examine the effects of social contact on cocaine intake in female rats, (2) examine the behavioral mechanisms by which social contact influences cocaine intake, and (3) examine whether the estrous cycle moderates the effects of social contact on cocaine intake. Female rats were assigned to either isolated or pair-housed conditions in which a social partner either had access to cocaine (cocaine partner) or did not have access to cocaine (abstinent partner). Pair-housed rats were tested in custom-built operant conditioning chambers that allowed both rats to be tested simultaneously in the same chamber. Rats housed with a cocaine partner self-administered more cocaine than isolated rats and rats housed with an abstinent partner. A behavioral economic analysis indicated that these differences were driven by a greater intensity of cocaine demand (i.e., greater intake at lower unit prices) in rats housed with a cocaine partner. Multivariate modeling revealed that the estrous cycle did not moderate the effects of social contact on cocaine intake. These findings indicate that: (1) social contact influences cocaine self-administration in females in a manner similar to that reported in males, (2) these effects are due to differences in the effects of social contact on the intensity of cocaine demand, and (3) these effects are consistent across all phases of the estrous cycle.
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性别，发情周期和社会接触对大鼠可卡因和海洛因自我管理的影响。
影响因子：
3.4
作者：
Lacy RT;Strickland JC;Feinstein MA;Robinson AM;Smith MA
通讯作者：
Smith MA
影响因子：
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作者：
Greenfield, Shelly F.;Back, Sudie E.;Lawson, Katie;Brady, Kathleen T.
通讯作者：
Brady, Kathleen T.
影响因子：
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作者：
Lacy, Ryan T.;Strickland, Justin C.;Smith, Mark A.
通讯作者：
Smith, Mark A.
影响因子：
1.6
作者：
Hubscher, CH;Brooks, DL;Johnson, JR
通讯作者：
Johnson, JR
影响因子：
--
作者：
MARCONDES, F. K.;BIANCHI, F. J.;TANNO, A. P.
通讯作者：
TANNO, A. P.