Neural correlates of encoding within- and across-domain inter-item associations.
Neural correlates of encoding within- and across-domain inter-item associations.
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DOI：
10.1162/jocn.2011.21611
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发表时间：
2011-09
影响因子：
3.2
通讯作者：
Rugg MD
中科院分区：
文献类型：
--
作者：
Park H;Rugg MD
比较了单词对、图片对和单词-图片对之间关联编码的神经相关性。目的是首先确定联想编码的神经相关性是否根据研究材料而变化，其次确定跨材料项目对与材料内项目对的编码是否与海马和鼻周活动的可分离模式相关，正如内侧颞叶（MTL）功能的“域二分法”假设所预测的那样。在进行功能磁共振成像扫描时，受试者（n = 24）被呈现出三类研究对，判断哪些指定的物体适合另一个。在扫描仪之外，受试者随后进行联想识别任务，区分完整的研究对、由不同研究试验中出现的项目组成的重新排列的研究对以及未研究的项目对。成功联想编码的神经关联——随后的联想记忆效应——被操作化为在随后的记忆测试中正确判断完整的研究对与被错误判断重新排列的研究对之间的活动差异。与类型无关的后续记忆效应在左额下回（IFG）和海马体中很明显。图片-图片对在梭状皮层区域引发了材料选择性效应，这些区域在图片试验中的激活程度也高于单词试验，而单词-单词对在左侧颞叶皮层中引发了材料选择性随后的记忆效应。与领域二分法假说相反，海马和鼻周的后续记忆效应都没有差异，这取决于它们是否是由材料内和跨材料研究对引起的。提出左 IFG 在联想编码中发挥域一般作用，联想编码也可以通过材料选择性皮层区域的增强处理来促进，并且海马和嗅周皮层对项目间关联的形成具有同等的贡献，无论项目属于相同还是不同的处理域。
The neural correlates of the encoding of associations between pairs of words, pairs of pictures, and word-picture pairs were compared. The aims were to determine first, whether the neural correlates of associative encoding vary according to study material and second, whether encoding of across- versus within-material item pairs is associated with dissociable patterns of hippocampal and perirhinal activity, as predicted by the ‘domain dichotomy’ hypothesis of medial temporal lobe (MTL) function. While undergoing fMRI scanning, subjects (n = 24) were presented with the three classes of study pairs, judging which of the denoted objects fit into the other. Outside of the scanner, subjects then undertook an associative recognition task, discriminating between intact study pairs, rearranged pairs comprising items that had been presented on different study trials, and unstudied item pairs. The neural correlates of successful associative encoding – subsequent associative memory effects – were operationalized as the difference in activity between study pairs correctly judged intact versus pairs incorrectly judged rearranged on the subsequent memory test. Pair type-independent subsequent memory effects were evident in the left inferior frontal gyrus (IFG) and the hippocampus. Picture-picture pairs elicited material-selective effects in regions of fusiform cortex that were also activated to a greater extent on picture trials than word trials, while word-word pairs elicited material-selective subsequent memory effects in left lateral temporal cortex. Contrary to the domain-dichotomy hypothesis, neither hippocampal nor perirhinal subsequent memory effects differed depending on whether they were elicited by within- versus across-material study pairs. It is proposed that the left IFG plays a domain-general role in associative encoding, that associative encoding can also be facilitated by enhanced processing in material-selective cortical regions, and that the hippocampus and perirhinal cortex contribute equally to the formation of inter-item associations regardless of whether the items belong to the same or to different processing domains.
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