Quantitative 4D transcatheter intraarterial perfusion MRI for monitoring chemoembolization of hepatocellular carcinoma.
Quantitative 4D transcatheter intraarterial perfusion MRI for monitoring chemoembolization of hepatocellular carcinoma.
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DOI：
10.1002/jmri.22155
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发表时间：
2010-05
影响因子：
4.4
通讯作者：
Larson, Andrew C.
中科院分区：
文献类型：
--
作者：
Wang, Dingxin;Jin, Brian;Lewandowski, Robert J.;Ryu, Robert K.;Sato, Kent T.;Mulcahy, Mary F.;Kulik, Laura M.;Miller, Frank H.;Salem, Riad;Li, Debiao;Omary, Reed A.;Larson, Andrew C.
To develop a fully quantitative 4D transcatheter intraarterial perfusion (TRIP) MRI technique and prospectively test the hypothesis that quantitative 4D TRIP-MRI can be used clinically to monitor intra-procedural liver tumor perfusion reductions during transcatheter arterial chemoembolization (TACE). TACE was performed within an x-ray DSA-MRI procedure suite in 16 patients with hepatocellular carcinoma. Quantitative 4D TRIP-MRI with targeted radiofrequency field mapping and dynamic longitudinal relaxation rate mapping was used to monitor changes in tumor perfusion during TACE. First-pass perfusion analysis was performed to produce intra-procedural blood flow (Fρ) maps. Mean liver tumor perfusions before and after TACE were compared with a paired t-test (α = 0.05). Perfusion reductions were successfully measured with quantitative 4D TRIP-MRI in 22 separate tumors during 18 treatment sessions. Mean tumor perfusion Fρ decreased from 16.3 (95% CI: 10.7–21.9) before TACE to 5.0 (95% CI: 3.5–6.5) (mL/min/100mL) after TACE. Tumor perfusion reductions were statistically significant (P < 0.0005), with a mean absolute perfusion change of 11.4 (95% CI: 5.6–17.1) (mL/min/100mL) and a mean percentage reduction of 61.0% (95% CI: 48.3%–73.6%). Quantitative 4D TRIP-MRI can be successfully performed within clinical interventional settings to monitor intra-procedural changes in liver tumor perfusion during TACE.
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影响因子：
19.7
作者：
Larson, Andrew C.;Wang, Dingxin;Omary, Reed A.
通讯作者：
Omary, Reed A.
影响因子：
19.7
作者：
Annet, L;Materne, R;Van Beers, BE
通讯作者：
Van Beers, BE
影响因子：
4.5
作者：
Kew, MC
通讯作者：
Kew, MC
影响因子：
2.9
作者：
El-Serag, HB
通讯作者：
El-Serag, HB
影响因子：
1.3
作者：
BLOMLEY, MJK;COULDEN, R;LIPTON, MJ
通讯作者：
LIPTON, MJ