Perceived discrimination is associated with the inflammatory response to acute laboratory stress in women at risk for cardiovascular disease.
Perceived discrimination is associated with the inflammatory response to acute laboratory stress in women at risk for cardiovascular disease.
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DOI：
10.1016/j.bbi.2018.07.010
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发表时间：
2018-10
期刊：
影响因子：
--
通讯作者：
Witek Janusek L
中科院分区：
文献类型：
--
作者：
Saban KL;Mathews HL;Bryant FB;Tell D;Joyce C;DeVon HA;Witek Janusek L
心血管疾病（CVD）是美国死亡的主要原因，对少数民族造成了不成比例的损失。越来越多的证据表明，感知到的歧视是心理困扰，慢性低度炎症和心血管健康的重要因素。然而，很少有人知道在何种程度上感知歧视有助于急性应激的炎症反应。因此，本研究的目的是研究的影响，感知歧视的炎症反应，以实验室急性应激范式在女性心血管疾病的风险。对99名绝经后妇女（50名非洲裔美国人和49名非西班牙裔白色人）（平均年龄60.2岁）进行了特里尔社会压力测试（TSST），这些妇女至少有两个CVD风险因素。受试者完成底特律地区研究辨别量表（DAS-DS）日常辨别子量表，并在TSST前和TSST后每15分钟至90分钟提供血液和唾液样本，以测量促炎细胞因子白细胞介素-6（IL-6）。在控制年龄、种族、婚姻状况、家庭收入、BMI、他汀类药物使用、儿童期虐待、抑郁症状和主观社会地位的情况下，感知歧视与唾液IL-6对TSST的反应显著相关（B = 0.49，SE = 0.13，p = <0.001）。与报告较低水平感知歧视的妇女相比，报告较高水平感知歧视的妇女在基线和TSST后唾液IL-6水平较高。结果表明，无论种族和社会经济地位如何，更高水平的感知歧视可能会在急性压力暴露之前和之后提高炎症水平。循环IL-6反应仅与BMI相关，与唾液IL-6无关。这些数据表明，感知歧视可能有助于唾液IL-6急性应激反应。然而，需要更多的研究来帮助澄清应激和唾液促炎细胞因子之间的复杂关系。
Cardiovascular disease (CVD) is the leading cause of death in the United States and exacts a disproportionate toll on minorities. Growing evidence demonstrates that perceived discrimination is a significant contributing factor to psychological distress, chronic low-grade inflammation, and cardiovascular health. However, little is known regarding the extent to which perceived discrimination contributes to the inflammatory response to acute stress. Therefore, the purpose of this study was to examine the influence of perceived discrimination on the inflammatory response to a laboratory acute stress paradigm in women at risk for CVD. A cross-sectional sample of 99 postmenopausal women (50 African American and 49 non-Hispanic White) (mean age 60.2 years) with at least two risk factors for CVD underwent the Trier Social Stress Test (TSST). Subjects completed the Detroit Area Study Discrimination Scale (DAS-DS) Everyday Discrimination subscale and provided blood and saliva samples prior to the TSST and every 15 minutes up to 90 minutes post-TSST to measure a pro- inflammatory cytokine, interleukin-6 (IL-6). Perceived discrimination was significantly associated with the salivary IL-6 response to the TSST (b = 0.49, SE = 0.13, p = <0.001) controlling for age, race, marital status, household income, BMI, statin use, childhood maltreatment, depressive symptoms, and subjective social status. Women who reported higher levels of perceived discrimination had higher levels of salivary IL-6 at baseline and following the TSST as compared to women who reported lower levels of perceived discrimination. Results suggest that higher levels of perceived discrimination, regardless of race and socioeconomic status, may heighten levels of inflammation, prior to and following an acute stress exposure. The circulating Il-6 response was associated with BMI only and did not correlate with salivary IL-6. These data suggest that perceived discrimination may contribute to the salivary-IL-6 acute stress response. However, more research is needed to help clarify the complex relationships among stress and salivary proinflammatory cytokines.
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DOI：
10.1038/npp.2010.159
发表时间：
2010-12
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
--
影响因子：
1.9
作者：
Carty CL;Heagerty P;Heckbert SR;Jarvik GP;Lange LA;Cushman M;Tracy RP;Reiner AP
通讯作者：
Reiner AP
影响因子：
3.9
作者：
Barber, Sharrelle;Hickson, DeMarc A.;Earls, Felton
通讯作者：
Earls, Felton
影响因子：
7.4
作者：
Dugan SA;Lewis TT;Everson-Rose SA;Jacobs EA;Harlow SD;Janssen I
通讯作者：
Janssen I
影响因子：
2.3
作者：
Cuevas, Adolfo G.;Reitzel, Lorraine R.;McNeill, Lorna H.
通讯作者：
McNeill, Lorna H.