Genetic evidence that higher central adiposity causes gastro-oesophageal reflux disease: a Mendelian randomization study.
Genetic evidence that higher central adiposity causes gastro-oesophageal reflux disease: a Mendelian randomization study.
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DOI：
10.1093/ije/dyaa082
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发表时间：
2020-08-01
影响因子：
7.7
通讯作者：
Tyrrell J
中科院分区：
文献类型：
--
作者：
Green HD;Beaumont RN;Wood AR;Hamilton B;Jones SE;Goodhand JR;Kennedy NA;Ahmad T;Yaghootkar H;Weedon MN;Frayling TM;Tyrrell J
胃食管反流病 (GORD) 与多种危险因素相关，但确定因果关系很困难。我们使用遗传方法 [孟德尔随机化 (MR)] 来识别 GORD 的潜在因果可改变危险因素。我们使用了英国生物银行 451 097 名欧洲参与者的数据，并使用医院定义的 ICD10 和 OPCS4 代码以及自我报告数据定义了 GORD（N = 41 024 GORD 病例）。我们测试了 GORD 与四种肥胖指标 [体重指数 (BMI)、腰臀比 (WHR)、代谢有利的较高体脂百分比和腰围]、吸烟状况、吸烟频率和咖啡因摄入量之间的观察性和基于 MR 的关联。据观察，所有肥胖指标均与较高的 GORD 发生率相关。曾经和现在吸烟与 GORD 发生率较高有关。咖啡摄入量与较低的 GORD 几率相关，但在咖啡饮用者中，摄入更多含咖啡因的咖啡与较高的 GORD 几率相关。使用 MR，我们提供了强有力的证据，表明较高的腰臀比和根据 BMI 调整的较高腰臀比会导致 GORD。没有证据表明较高的 BMI、体脂百分比、喝咖啡或吸烟会导致 GORD，但只能排除 BMI 和体脂百分比的观察效应。 MR 对腰臀比的估计效果相当于腰围每增加 5 厘米，GORD 的几率就会增加 1.23 倍。这些结果提供了强有力的证据，表明较高的腰臀比会导致 GORD。我们的研究表明，中央脂肪分布对于导致胃食管反流病至关重要，而不是总体体重。
Gastro-oesophageal reflux disease (GORD) is associated with multiple risk factors but determining causality is difficult. We used a genetic approach [Mendelian randomization (MR)] to identify potential causal modifiable risk factors for GORD. We used data from 451 097 European participants in the UK Biobank and defined GORD using hospital-defined ICD10 and OPCS4 codes and self-report data (N = 41 024 GORD cases). We tested observational and MR-based associations between GORD and four adiposity measures [body mass index (BMI), waist–hip ratio (WHR), a metabolically favourable higher body-fat percentage and waist circumference], smoking status, smoking frequency and caffeine consumption. Observationally, all adiposity measures were associated with higher odds of GORD. Ever and current smoking were associated with higher odds of GORD. Coffee consumption was associated with lower odds of GORD but, among coffee drinkers, more caffeinated-coffee consumption was associated with higher odds of GORD. Using MR, we provide strong evidence that higher WHR and higher WHR adjusted for BMI lead to GORD. There was weak evidence that higher BMI, body-fat percentage, coffee drinking or smoking caused GORD, but only the observational effects for BMI and body-fat percentage could be excluded. This MR estimated effect for WHR equates to a 1.23-fold higher odds of GORD per 5-cm increase in waist circumference. These results provide strong evidence that a higher waist–hip ratio leads to GORD. Our study suggests that central fat distribution is crucial in causing GORD rather than overall weight.
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影响因子：
64.8
作者：
Bycroft C;Freeman C;Petkova D;Band G;Elliott LT;Sharp K;Motyer A;Vukcevic D;Delaneau O;O'Connell J;Cortes A;Welsh S;Young A;Effingham M;McVean G;Leslie S;Allen N;Donnelly P;Marchini J
通讯作者：
Marchini J
影响因子：
3.5
作者：
Pulit SL;Stoneman C;Morris AP;Wood AR;Glastonbury CA;Tyrrell J;Yengo L;Ferreira T;Marouli E;Ji Y;Yang J;Jones S;Beaumont R;Croteau-Chonka DC;Winkler TW;GIANT Consortium;Hattersley AT;Loos RJF;Hirschhorn JN;Visscher PM;Frayling TM;Yaghootkar H;Lindgren CM
通讯作者：
Lindgren CM
影响因子：
2.1
作者：
Bowden J;Davey Smith G;Haycock PC;Burgess S
通讯作者：
Burgess S
影响因子：
4.5
作者：
Ha NR;Lee HL;Lee OY;Yoon BC;Choi HS;Hahm JS;Ahn YH;Koh DH
通讯作者：
Koh DH
影响因子：
30.8
作者：
Loh, Po-Ru;Tucker, George;Bulik-Sullivan, Brendan K.;Vilhjalmsson, Bjarni J.;Finucane, Hilary K.;Salem, Rany M.;Chasman, Daniel I.;Ridker, Paul M.;Neale, Benjamin M.;Berger, Bonnie;Patterson, Nick;Price, Alkes L.
通讯作者：
Price, Alkes L.