Differences in clinical characteristics between patients with non-erosive reflux disease and erosive esophagitis in Korea.
Differences in clinical characteristics between patients with non-erosive reflux disease and erosive esophagitis in Korea.
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DOI：
10.3346/jkms.2010.25.9.1318
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发表时间：
2010-09
影响因子：
4.5
通讯作者：
Koh DH
中科院分区：
文献类型：
--
作者：
Ha NR;Lee HL;Lee OY;Yoon BC;Choi HS;Hahm JS;Ahn YH;Koh DH
胃食管反流病（GERD）是由胃内容物异常反流到食管引起的。GERD可分为两组，糜烂性食管炎和非糜烂性反流病（NERD）。本研究的目的是比较糜烂性食管炎患者与NERD患者的临床特征。所有参与的患者在自愿健康检查期间接受了上消化道内窥镜检查。NERD组由500名在上消化道内镜检查期间无食管粘膜损伤的典型GERD症状的受试者组成。糜烂性食管炎组包括292例浅表食管糜烂伴或不伴GERD典型症状的受试者。在GERD患者中，与NERD相比，男性、高体重指数、高肥胖程度、高腰臀比、高甘油三酯、饮酒、吸烟和存在食管裂孔疝与糜烂性食管炎的发生呈正相关。在多变量分析中，男性、腰臀比和存在食管裂孔疝是糜烂性食管炎的重要危险因素。我们认为糜烂性食管炎与腹型肥胖关系更为密切。
Gastroesophageal reflux disease (GERD) is caused by abnormal reflux of gastric contents into the esophagus. GERD can be divided into two groups, erosive esophagitis and non-erosive reflux disease (NERD). The aim of this study was to compare the clinical characteristics of patients with erosive esophagitis to those with NERD. All participating patients underwent an upper endoscopy during a voluntary health check-up. The NERD group consisted of 500 subjects with classic GERD symptoms in the absence of esophageal mucosal injury during upper endoscopy. The erosive esophagitis group consisted of 292 subjects with superficial esophageal erosions with or without typical symptoms of GERD. Among GERD patients, male gender, high body mass index, high obesity degree, high waist-to-hip ratio, high triglycerides, alcohol intake, smoking and the presence of a hiatal hernia were positively related to the development of erosive esophagitis compared to NERD. In multivariated analysis, male gender, waist-to-hip ratio and the presence of a hiatal hernia were the significant risk factors of erosive esophagitis. We suggest that erosive esophagitis was more closely related to abdominal obesity.
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影响因子：
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DOI：
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