Genetic-Based Dissection Unveils the Inputs and Outputs of Striatal Patch and Matrix Compartments.
Genetic-Based Dissection Unveils the Inputs and Outputs of Striatal Patch and Matrix Compartments.
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DOI：
10.1016/j.neuron.2016.07.046
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发表时间：
2016-09-07
期刊：
影响因子：
16.2
通讯作者：
Jin X
中科院分区：
文献类型：
--
作者：
Smith JB;Klug JR;Ross DL;Howard CD;Hollon NG;Ko VI;Hoffman H;Callaway EM;Gerfen CR;Jin X
纹状体包含神经化学定义的区室，称为斑块和基质。先前的研究表明，斑块优先接收边缘输入并投射到黑质（SNc）的多巴胺神经元，而基质神经元接收感觉运动输入并且不支配 SNc。使用具有病毒追踪技术的 BAC-Cre 转基因小鼠，我们绘制了贴片/矩阵输入输出组织的全脑差异。研究结果揭示了被称为“外贴片”的纹状体贴片神经元的移位群体，它们驻留在基质区域，但具有类似于贴片神经元的神经化学、连接性和电生理学特征。与之前的研究相反，结果显示贴片/外贴片和基质神经元接收边缘和感觉运动信息。揭示了从终纹床核到斑块/外斑块神经元的新型抑制投射。发现对 SNc 的投射源自贴片/外贴片和矩阵神经元。这些发现重新定义了传统神经化学拓扑结构之外的贴片/矩阵，并揭示了有关其输入输出连接的新原理，为未来的功能研究奠定了基础。 Smith、Klug、Ross 等人使用 BAC-Cre 转基因小鼠进行 Cre 依赖性病毒追踪、电生理学和光遗传学。揭示新的纹状体电路并重新定义纹状体斑块和基质区室的输入输出组织。
The striatum contains neurochemically defined compartments termed patches and matrix. Previous studies suggest patches preferentially receive limbic inputs and project to dopamine neurons in substantia nigra (SNc), whereas matrix neurons receive sensorimotor inputs and do not innervate SNc. Using BAC-Cre transgenic mice with viral tracing techniques we mapped brain-wide differences in the input-output organization of the patch/matrix. Findings reveal a displaced population of striatal patch neurons termed “exo-patch”, which reside in matrix zones but have neurochemistry, connectivity, and electrophysiological characteristics resembling patch neurons. Contrary to previous studies, results show patch/exo-patch and matrix neurons receive both limbic and sensorimotor information. A novel inhibitory projection from bed nucleus of the stria terminalis to patch/exo-patch neurons was revealed. Projections to SNc were found to originate from patch/exo-patch and matrix neurons. These findings redefine patch/matrix beyond traditional neurochemical topography and reveal new principles about their input-output connectivity, providing a foundation for future functional studies. Using BAC-Cre transgenic mice with Cre-dependent viral tracing, electrophysiology and optogenetics, Smith, Klug, Ross et al. reveal new striatal circuitry and redefine the input-output organization of striatal patch and matrix compartments.
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影响因子：
16.2
作者：
Banghart MR;Neufeld SQ;Wong NC;Sabatini BL
通讯作者：
Sabatini BL
影响因子：
5.3
作者：
Blomeley, Craig P.;Bracci, Enrico
通讯作者：
Bracci, Enrico
影响因子：
2.9
作者：
Crittenden JR;Graybiel AM
通讯作者：
Graybiel AM
DOI：
10.1073/pnas.82.24.8780
发表时间：
1985-12-01
影响因子：
11.1
作者：
GERFEN, CR;BAIMBRIDGE, KG;MILLER, JJ
通讯作者：
MILLER, JJ
影响因子：
2.5
作者：
GERFEN, CR
通讯作者：
GERFEN, CR