The medial temporal lobes are critical for reward-based decision making under conditions that promote episodic future thinking.
The medial temporal lobes are critical for reward-based decision making under conditions that promote episodic future thinking.
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DOI：
10.1002/hipo.22376
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发表时间：
2015-03
期刊：
影响因子：
3.5
通讯作者：
Verfaellie, Mieke
中科院分区：
文献类型：
--
作者：
Palombo, Daniela J.;Keane, Margaret M.;Verfaellie, Mieke
在本研究中，我们研究了内侧颞叶（MTL）损伤对人类基于奖励的跨期选择决策的影响。在跨期选择中，人们通常会贬值（或打折）未来奖励，以解释其延迟到来的原因（例如，比起2个月后的42美元，人们更喜欢现在的30美元），但当参与者进行情景未来思考时，这种影响就会减弱，即，将自己投射到未来，想象一个特定的事件。我们假设这种衰减会在失忆症患者中选择性地受损，这些患者在偶发性未来思维方面存在缺陷。重复先前的工作，在一个标准的跨期选择任务中，健忘症患者表现出与健康对照组相似的时间折扣指数。与我们的假设一致，在要求参与者首先进行情景性未来思考（例如，想象在2个月内在剧院花费42美元）的条件下，健康对照组表现出减弱的时间折扣，而健忘症患者没有表现出这种效果。此外，正如预期的那样，失忆症患者的叙述比对照组的情节更少。这些发现扩大了MTL依赖任务的范围，不仅包括基于记忆的决策任务，还包括面向未来的任务。
In the present study, we investigated the effect of medial temporal lobe (MTL) damage on human decision making in the context of reward-based intertemporal choice. During intertemporal choice, humans typically devalue (or discount) a future reward to account for its delayed arrival (e.g., preferring $30 now over $42 in 2 months), but this effect is attenuated when participants engage in episodic future thinking, i.e., project themselves into the future to imagine a specific event. We hypothesized that this attenuation would be selectively impaired in amnesic patients, who have deficits in episodic future thinking. Replicating previous work, in a standard intertemporal choice task, amnesic patients showed temporal discounting indices similar to healthy controls. Consistent with our hypothesis, while healthy controls demonstrated attenuated temporal discounting in a condition that required participants first to engage in episodic future thinking (e.g., to imagine spending $42 at a theatre in 2 months), amnesic patients failed to demonstrate this effect. Moreover, as expected, amnesic patients’ narratives were less episodically rich than those of controls. These findings extend the range of tasks that are shown to be MTL dependent to include not only memory-based decision-making tasks but also future-oriented ones.
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影响因子：
4.3
作者：
Bornstein AM;Daw ND
通讯作者：
Daw ND
DOI：
10.1111/j.1460-9568.2012.08058.x
发表时间：
2012-04
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Kurth-Nelson Z;Bickel W;Redish AD
通讯作者：
Redish AD
影响因子：
5.7
作者：
Ballard K;Knutson B
通讯作者：
Knutson B
影响因子：
2.7
作者：
Johnson, MW;Bickel, WK
通讯作者：
Bickel, WK
影响因子：
16.2
作者：
Peters, Jan;Buechel, Christian
通讯作者：
Buechel, Christian