Shift work and breast cancer among women textile workers in Shanghai, China.
Shift work and breast cancer among women textile workers in Shanghai, China.
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DOI：
10.1007/s10552-014-0493-0
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发表时间：
2015-01
影响因子：
2.3
通讯作者：
Checkoway, Harvey
中科院分区：
文献类型：
--
作者：
Li, Wenjin;Ray, Roberta M.;Thomas, David B.;Davis, Scott;Yost, Michael;Breslow, Norman;Gao, Dao Li;Fitzgibbons, E. Dawn;Camp, Janice E.;Wong, Eva;Wernli, Karen J.;Checkoway, Harvey
尽管在许多流行病学研究中夜班工作与乳腺癌风险升高有关，但证据并不一致。我们进行了一项巢式病例队列研究，以调查中国上海纺织女工的一个大型队列中轮班工作（包括夜班）与乳腺癌风险之间的可能关联。该研究包括1709例乳腺癌病例和4780例非病例。历史轮班工作时间表的数据收集分类的工作从工厂的研究对象工作过，然后被链接到每个主题的完整的工作历史。工厂里没有一份工作是专门上夜班的。因此，将夜班作为轮班工作模式的一部分进行评价。风险比和95%置信区间采用适合于病例队列设计的考克斯比例风险模型计算夜班工作年数和总工作夜数。此外，对滞后10年和20年的暴露进行了重复分析。我们观察到，无论滞后时间如何，这与整个就业期间的夜班工作年数或工作夜数都没有联系。年龄分层分析的结果与整个研究人群中观察到的结果非常相似。这项研究的结果没有提供任何证据支持轮班工作会增加乳腺癌风险的假设。在西方人群中观察到的轮班工作与乳腺癌之间的正相关性，但在本研究和其他中国人群的研究中没有观察到，这表明轮班工作对乳腺癌风险的影响在亚洲和高加索女性中可能不同。
Although night shift work has been associated with elevated risk of breast cancer in numerous epidemiologic studies, evidence is not consistent. We conducted a nested case-cohort study to investigate a possible association between shift work including a night shift and risk of breast cancer within a large cohort of women textile workers in Shanghai, China. The study included 1709 incident breast cancer cases and 4780 non-cases. Data on historical shift-work schedules were collected by categorized jobs from the factories where the study subjects had worked, and then were linked to the complete work histories of each subject. No jobs in the factories involved exclusively night shift work. Therefore, night shift was evaluated as part of a rotating shift work pattern. Hazard ratios and 95% confidence intervals were calculated using Cox proportional hazards modeling adapted for the case-cohort design for years of night-shift work and the total number of nights worked. Additionally, analyses were repeated with exposures lagged by 10 and 20 years. We observed no associations with either years of night-shift work, or number of nights worked during the entire employment period, irrespective of lag intervals. Findings from the age-stratified analyses were very similar to those observed for the entire study population. The findings from this study provide no evidence to support the hypothesis that shift work increases breast cancer risk. The positive association between shift work and breast cancer observed in Western populations, but not observed in this and other studies of the Chinese population, suggest that the effect of shift work on breast cancer risk may be different in Asian and Caucasian women.
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影响因子：
51.1
作者：
Straif, Kurt;Baan, Robert;Cogliano, Vincent
通讯作者：
Cogliano, Vincent
影响因子：
6.3
作者：
Schwartzbaum, Judith;Ahlbom, Anders;Feychting, Maria
通讯作者：
Feychting, Maria
DOI：
10.1152/ajpregu.00355.2006
发表时间：
2007-06-01
影响因子：
2.8
作者：
Higuchi, Shigekazu;Motohashi, Yutaka;Maeda, Takafumi
通讯作者：
Maeda, Takafumi
影响因子：
10.3
作者：
Astrakianakis, George;Seixas, Noah S.;Checkoway, Harvey
通讯作者：
Checkoway, Harvey
影响因子：
5.4
作者：
Hansen, J
通讯作者：
Hansen, J