The Prospective Application of Melatonin in Treating Epigenetic Dysfunctional Diseases.
The Prospective Application of Melatonin in Treating Epigenetic Dysfunctional Diseases.
复制标题
褪黑素在治疗表观遗传功能障碍疾病中的前瞻性应用
DOI：
10.3389/fphar.2022.867500
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发表时间：
2022
影响因子：
5.6
通讯作者：
Liu, Xin
中科院分区：
文献类型：
--
作者：
Monayo, Seth Mikaye;Liu, Xin
In the past, different human disorders were described by scientists from the perspective of either environmental factors or just by genetically related mechanisms. The rise in epigenetic studies and its modifications, i.e., heritable alterations in gene expression without changes in DNA sequences, have now been confirmed in diseases. Modifications namely, DNA methylation, posttranslational histone modifications, and non-coding RNAs have led to a better understanding of the coaction between epigenetic alterations and human pathologies. Melatonin is a widely-produced indoleamine regulator molecule that influences numerous biological functions within many cell types. Concerning its broad spectrum of actions, melatonin should be investigated much more for its contribution to the upstream and downstream mechanistic regulation of epigenetic modifications in diseases. It is, therefore, necessary to fill the existing gaps concerning corresponding processes associated with melatonin with the physiological abnormalities brought by epigenetic modifications. This review outlines the findings on melatonin’s action on epigenetic regulation in human diseases including neurodegenerative diseases, diabetes, cancer, and cardiovascular diseases. It summarizes the ability of melatonin to act on molecules such as proteins and RNAs which affect the development and progression of diseases.
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影响因子：
3.8
作者：
Arrighetti, Noemi;Cossa, Giacomo;Gatti, Laura
通讯作者：
Gatti, Laura
影响因子：
5.6
作者：
Bondy SC;Campbell A
通讯作者：
Campbell A
影响因子：
7.3
作者：
Bahna, Sarra G.;Niles, Lennard P.
通讯作者：
Niles, Lennard P.
DOI：
10.1177/1073858417707457
发表时间：
2018-04
期刊：
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
影响因子：
--
作者：
Bayraktar G;Kreutz MR
通讯作者：
Kreutz MR
影响因子：
11.8
作者：
Akkers, Robert C.;van Heeringen, Simon J.;Jacobi, Ulrike G.;Janssen-Megens, Eva M.;Francoijs, Kees-Jan;Stunnenberg, Hendrik G.;Veenstra, Gert Jan C.
通讯作者：
Veenstra, Gert Jan C.