Mechanisms Underlying Tumor Suppressive Properties of Melatonin.
Mechanisms Underlying Tumor Suppressive Properties of Melatonin.
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DOI：
10.3390/ijms19082205
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发表时间：
2018-07-27
影响因子：
5.6
通讯作者：
Campbell A
中科院分区：
文献类型：
--
作者：
Bondy SC;Campbell A
有相当多的证据表明，褪黑激素可用于预防和治疗癌症。这篇文章将回顾一些人类、动物和细胞的研究，这些研究提供了褪黑激素具有抑瘤特性的证据。褪黑激素缓解癌症发病机制的确认将从其对致癌作用的直接研究和间接研究结果暗示昼夜节律周期的中断来描述。褪黑激素在防止肿瘤发生途径的启动中的作用与褪黑激素延缓癌症进展的能力之间存在区别。褪黑激素似乎减缓了已建立的肿瘤的进展速度，并且有证据表明它构成了标准药理学和放射治疗方式的有价值的补充。在癌症治疗中，有一些利用一系列激素和维生素的有益结果的例子，褪黑激素是其中的成分之一。虽然这些复杂的共混物是经验上有前途的，他们只是简要地提到了在这里的混杂影响的多种代理商同时研究。本文的最后一部分探讨了褪黑激素抑制肿瘤作用的分子机制。各种转录因子激活后基因表达的改变可能是重要的介导事件。这些基因活性的变化不仅与癌症有关，而且与大多数肿瘤发病的衰老过程有关。此外，需要考虑表观遗传事件，如在生物体的整个生命周期中组蛋白乙酰化和DNA甲基化模式的调节。褪黑激素的抗氧化和免疫调节作用也可能有助于其癌症调节特性。自然，这些机制相互重叠，并广泛地相互作用。然而，为了清晰和便于阅读，每一个都作为一个单独的主题部分进行讨论。报告最后得出了一些关于褪黑激素的临床价值的一般性结论，这些结论被忽视和研究不足。
There is considerable evidence that melatonin may be of use in the prevention and treatment of cancer. This manuscript will review some of the human, animal and cellular studies that provide evidence that melatonin has oncostatic properties. Confirmation that melatonin mitigates pathogenesis of cancer will be described from both direct study of its effects on carcinogenesis, and from indirect findings implicating disruption of the circadian cycle. A distinction is made between the role of melatonin in preventing the initiation of the tumorigenic pathway and the ability of melatonin to retard the progression of cancer. Melatonin appears to slow down the rate of advancement of established tumors and there is evidence that it constitutes a valuable complement to standard pharmacological and radiation treatment modalities. There are instances of the beneficial outcomes in cancer treatment which utilize a range of hormones and vitamins, melatonin being among the constituents of the mix. While these complex blends are empirically promising, they are only briefly mentioned here in view of the confounding influence of a multiplicity of agents studied simultaneously. The last section of this review examines the molecular mechanisms that potentially underlie the oncostatic effects of melatonin. Alterations in gene expression following activation of various transcription factors, are likely to be an important mediating event. These changes in gene activity not only relate to cancer but also to the aging process which underlies the onset of most tumors. In addition, epigenetic events such as modulation of histone acetylation and DNA methylation patterns throughout the lifespan of organisms need to be considered. The antioxidant and immunoregulatory roles of melatonin may also contribute to its cancer modulatory properties. Naturally, these mechanisms overlap and interact extensively. Nevertheless, in the interest of clarity and ease of reading, each is discussed as a separate topic section. The report ends with some general conclusions concerning the clinical value of melatonin which has been rather overlooked and understudied.
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影响因子：
10.3
作者：
Borin TF;Arbab AS;Gelaleti GB;Ferreira LC;Moschetta MG;Jardim-Perassi BV;Iskander AS;Varma NR;Shankar A;Coimbra VB;Fabri VA;de Oliveira JG;Zuccari DA
通讯作者：
Zuccari DA
DOI：
10.1196/annals.1308.032
发表时间：
2004-01-01
期刊：
ADOLESCENT BRAIN DEVELOPMENT: VULNERABILITIES AND OPPORTUNITIES
影响因子：
--
作者：
Carskadon, MA;Acebo, C;Jenni, OG
通讯作者：
Jenni, OG
夜间暴露在光线下造成的昼夜节律和褪黑激素的破坏会导致乳腺癌对他莫昔芬治疗产生内在耐药性。
影响因子：
11.2
作者：
Dauchy RT;Xiang S;Mao L;Brimer S;Wren MA;Yuan L;Anbalagan M;Hauch A;Frasch T;Rowan BG;Blask DE;Hill SM
通讯作者：
Hill SM
影响因子：
2.9
作者：
Cutando A;López-Valverde A;DE Vicente J;Gimenez JL;Carcía IA;DE Diego RG
通讯作者：
DE Diego RG
影响因子：
14.5
作者：
Bourboulia D;Stetler-Stevenson WG
通讯作者：
Stetler-Stevenson WG