A review of molecular mechanisms of the anti-leukemic effects of phenolic compounds in honey.
A review of molecular mechanisms of the anti-leukemic effects of phenolic compounds in honey.
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DOI：
10.3390/ijms131115054
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发表时间：
2012-11-15
影响因子：
5.6
通讯作者：
Suen AB
中科院分区：
文献类型：
--
作者：
Abubakar MB;Abdullah WZ;Sulaiman SA;Suen AB
国际癌症研究机构(IARC)2008年通过GLOBOCAN系列报告，恶性血液病约占所有新发癌症病例的9%。到目前为止，传统的治疗和手术治疗癌症的方法还不能遏制包括血液系统恶性肿瘤在内的全球癌症发病率的上升。在过去的十年里，人们对酚类化合物的生物活性产生了极大的研究兴趣，这些生物活性包括抗癌、抗氧化和抗炎等。许多抗癌药物通过细胞周期停滞、诱导细胞凋亡和分化，以及通过抑制细胞生长和增殖，或通过两种或两种以上机制的组合来抗癌。据报道，来自不同来源的各种酚类化合物通过这些机制之一发挥作用，成为很有前途的抗癌药物。蜂蜜具有悠久的医疗和营养消费历史，含有多种酚类化合物，如类黄酮类、酚酸、香豆素和单宁。本文综述了多种酚类化合物抗白血病作用的细胞周期、细胞生长增殖和细胞凋亡的分子机制，并主张进一步研究蜂蜜在白血病的化学预防和化疗中的潜在作用。
Hematologic malignancies constitute about 9% of all new cases of cancers as reported via the GLOBOCAN series by International Agency for Research on Cancer (IARC) in 2008. So far, the conventional therapeutic and surgical approaches to cancer therapy have not been able to curtail the rising incidence of cancers, including hematological malignancies, worldwide. The last decade has witnessed great research interest in biological activities of phenolic compounds that include anticancer, anti-oxidation and anti-inflammation, among other things. A large number of anticancer agents combat cancer through cell cycle arrest, induction of apoptosis and differentiation, as well as through inhibition of cell growth and proliferation, or a combination of two or more of these mechanisms. Various phenolic compounds from different sources have been reported to be promising anticancer agents by acting through one of these mechanisms. Honey, which has a long history of human consumption both for medicinal and nutritional uses, contains a variety of phenolic compounds such as flavonoids, phenolic acids, coumarins and tannins. This paper presents a review on the molecular mechanisms of the anti-leukemic activity of various phenolic compounds on cell cycle, cell growth and proliferation and apoptosis, and it advocates that more studies should be conducted to determine the potential role of honey in both chemoprevention and chemotherapy in leukemia.
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影响因子：
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作者：
Ghashm, Abdulmlik A.;Othman, Nor H.;Saini, Rajan
通讯作者：
Saini, Rajan
影响因子：
6.1
作者：
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9.7
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作者：
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影响因子：
4.8
作者：
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通讯作者：
Li-Weber, Min