Association between polymorphisms in the promoter regions of matrix metalloproteinases (MMPs) and risk of cancer metastasis: a meta-analysis.
Association between polymorphisms in the promoter regions of matrix metalloproteinases (MMPs) and risk of cancer metastasis: a meta-analysis.
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基质金属蛋白酶（MMP）启动子区域的多态性与癌症转移风险之间的关联：荟萃分析。
DOI：
10.1371/journal.pone.0031251
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Bai Y
中科院分区：
文献类型：
--
作者：
Liu D;Guo H;Li Y;Xu X;Yang K;Bai Y
各种研究已经评估了基质金属蛋白酶启动子区域多态性与癌症转移之间的关系。然而，结果仍然没有定论。为了更好地了解MMP多态性在转移中的作用，我们进行了一项全面的荟萃分析。检索电子数据库（从2000年1月到2011年6月），查找任何MMP与转移的遗传关联研究。进行总体和亚组分析。比值比（OR）和95%置信区间（CI）用于评估MMP多态性与转移之间的关系。使用Review Manager 5.0和STATA11.0进行统计分析。33项研究分析了10516例癌症患者的5种MMP多态性（4059例转移阳性病例和6457例转移阴性病例）。对于MMP1(−1607)1G/2G，基因型2G/2G增加了隐性模型下转移的总体风险（OR = 1.44, 95% CI = 1.05-1.98）。在基于癌症类型的亚组分析中，隐性模型下的头颈癌和乳腺癌存在关联，显性模型下的乳腺癌也存在关联。对于MMP3 (- 1171) 5A/6A，在两种遗传模式下，多态性降低了转移的总体风险（隐性：OR = 0.80, 95%CI = 0.64-0.99，显性：OR = 0.72, 95%CI = 0.56-0.93）。MMP7(−181)A/G和MMP9(−1562)C/T的多态性增加了转移风险。然而，没有观察到MMP2 (- 1306) C/T与转移之间的关联。我们的研究表明，MMP1、3、7和9启动子区域的多态性可能与某些癌症的转移有关。需要对MMP2进行进一步的大样本量研究。
A variety of studies have evaluated the associations between polymorphisms in the promoter regions of Matrix metalloproteinases (MMPs) and cancer metastasis. However, the results remain inconclusive. To better understand the roles of MMP polymorphisms in metastasis, we conducted a comprehensive meta-analysis. Electronic databases were searched (from January 2000 to June 2011) for any MMP genetic association studies in metastasis. Overall and subgroup analyses were performed. Odds ratio (OR) and 95% confidence interval (CI) were used to evaluate the associations between MMP polymorphisms and metastasis. Statistical analysis was performed with Review Manager 5.0 and STATA11.0. Thirty-three studies addressing five MMP polymorphisms were analyzed among 10,516 cancer cases (4,059 metastasis-positive cases and 6,457 metastasis-negative cases). For MMP1 (−1607)1G/2G, genotype 2G/2G increased the overall risk of metastasis under the recessive model (OR = 1.44, 95% CI = 1.05–1.98). In subgroup analysis based on cancer type, associations were found in head/neck and breast cancer under the recessive model, and also in breast cancer under the dominant model. For MMP3 (−1171) 5A/6A, the polymorphism decreased the overall risk of metastasis under two genetic models (recessive: OR = 0.80, 95%CI = 0.64–0.99, dominant: OR = 0.72, 95%CI = 0.56–0.93). The polymorphisms of MMP7 (−181) A/G and MMP9 (−1562) C/T increased metastatic risk. However, no association was observed between MMP2 (−1306) C/T and metastasis. Our investigations demonstrate that polymorphisms in the promoter regions of MMP1, 3, 7 and 9 might be associated with metastasis in some cancers. Further studies with large sample size for MMP2 should be conducted.
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影响因子：
4.7
作者：
Lai, HC;Chu, CM;Chu, TY
通讯作者：
Chu, TY
影响因子：
1.6
作者：
Albayrak, Selami;Canguven, Oender;Koksal, Vedat
通讯作者：
Koksal, Vedat
影响因子：
11.5
作者：
Hughes, Simon;Agbaje, Olorunsola;Jones, J. Louise
通讯作者：
Jones, J. Louise
DOI：
10.1007/s00432-004-0543-1
发表时间：
2004-05-01
影响因子：
3.6
作者：
Matsumura, S;Oue, N;Yasui, W
通讯作者：
Yasui, W
影响因子：
8.4
作者：
Curran, S;Murray, GI
通讯作者：
Murray, GI