Bioadhesives for musculoskeletal tissue regeneration.
Bioadhesives for musculoskeletal tissue regeneration.
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DOI：
10.1016/j.actbio.2020.09.050
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发表时间：
2020-11
影响因子：
9.7
通讯作者：
Lee CH
中科院分区：
文献类型：
--
作者：
Tarafder S;Park GY;Felix J;Lee CH
设计用于粘附生物成分的天然或合成材料，生物粘合剂，在诊所和手术中受到了极大的关注。因此，有几种市售的、fda批准的生物粘合剂用于皮肤伤口愈合、止血和密封软组织中的组织间隙或裂缝。近年来，生物胶粘剂的应用已扩展到肌肉骨骼组织工程和再生医学等各个领域。在组织表面立即建立强大的粘附力已显示出增强结缔组织修复的潜力。生物胶粘剂也被应用于将组织移植物固定到宿主体内，并填充或密封由损伤或退行性疾病引起的肌肉骨骼组织间隙。此外，具有即时黏附形成的可注射性可能为生物黏附剂作为细胞、生长因子和小分子的局部递送载体提供了巨大的潜力，以促进组织愈合和再生。本文综述了近年来生物胶粘剂在肌肉骨骼组织修复和再生中的应用研究进展。我们还讨论了生物胶粘剂的优势和突出的挑战，以及对高机械要求的结缔组织再生的未来展望。
Natural or synthetic materials designed to adhere to biological components, bioadhesives, have received significant attention in clinics and surgeries. As a result, there are several commercially available, FDA-approved bioadhesives used for skin wound closure, hemostasis, and sealing tissue gaps or cracks in soft tissues. Recently, the application of bioadhesives has been expanded to various areas including musculoskeletal tissue engineering and regenerative medicine. The instant establishment of a strong adhesion force on tissue surfaces has shown potential to augment repair of connective tissues. Bioadhesives have also been applied to secure tissue grafts to host bodies and to fill or seal gaps in musculoskeletal tissues caused by injuries or degenerative diseases. In addition, the injectability equipped with the instant adhesion formation may provide the great potential of bioadhesives as vehicles for localized delivery of cells, growth factors, and small molecules to facilitate tissue healing and regeneration. This review covers recent research progress in bioadhesives as focused on their applications in musculoskeletal tissue repair and regeneration. We also discuss the advantages and outstanding challenges of bioadhesives, as well as the future perspective toward regeneration of connective tissues with high mechanical demand.
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DOI：
10.1088/1748-6041/6/1/015014
发表时间：
2011-02
期刊：
Biomedical materials (Bristol, England)
影响因子：
--
作者：
Brodie M;Vollenweider L;Murphy JL;Xu F;Lyman A;Lew WD;Lee BP
通讯作者：
Lee BP
影响因子：
14
作者：
Brubaker, Carrie E.;Kissler, Hermann;Wang, Ling-Jia;Kaufman, Dixon B.;Messersmith, Phillip B.
通讯作者：
Messersmith, Phillip B.
影响因子：
9.7
作者：
Bochynska, A. I.;Van Tienen, T. G.;Grijpma, D. W.
通讯作者：
Grijpma, D. W.
DOI：
10.1007/s10856-016-5790-6
发表时间：
2017-01
期刊：
Journal of materials science. Materials in medicine
影响因子：
--
作者：
Bochyńska AI;Hannink G;Janssen D;Buma P;Grijpma DW
通讯作者：
Grijpma DW
影响因子：
2.7
作者：
Ayan, Irfan;Colak, Mehmet;Kuyurtar, Fehmi
通讯作者：
Kuyurtar, Fehmi