Regeneration mechanism for skin and peripheral nerves clarified at the organ and molecular scales.
Regeneration mechanism for skin and peripheral nerves clarified at the organ and molecular scales.
复制标题
DOI：
10.1016/j.cobme.2017.12.002
复制
发表时间：
2018-06
影响因子：
3.9
通讯作者：
So PTC
中科院分区：
文献类型：
--
作者：
Yannas IV;Tzeranis DS;So PTC
本文就近年来胶原支架材料在皮肤和周围神经再生中的作用机制，特别是临床上广泛应用的真皮再生模板（DRT）的研究进展进行综述。DRT改变正常的伤口愈合过程，将其从通过收缩和瘢痕形成的伤口闭合转换为通过再生的闭合。DRT通过阻断伤口收缩实现这种修饰，这自发地导致疤痕形成的取消，这是一个继发于收缩的过程。DRT的收缩阻断是收缩细胞（肌成纤维细胞，MFB）中显著的表型变化的结果，这是在整合素α1β1和α2β1特异性结合到六肽配体（可能是GFOGER和GLOGER）上后发生的，这些配体天然存在于DRT中胶原纤维表面。基于使用DRT的器官再生方法最近已从创伤皮肤扩展到患病皮肤。将该方法成功地扩展到通过收缩愈合伤口的其他器官是非常有可能的，尽管尚未尝试。这种再生范例在基本的机制理解和临床应用方面都比基于组织培养或干细胞的方法先进得多。它在很大程度上也没有风险，并且已经显示出比器官移植更低的发病率和更低的成本。
This article is a review of current research on the mechanism of regeneration of skin and peripheral nerves based on use of collagen scaffolds, particularly the dermis regeneration template (DRT), which is widely used clinically. DRT modifies the normal wound healing process, converting it from wound closure by contraction and scar formation to closure by regeneration. DRT achieves this modification by blocking wound contraction, which spontaneously leads to cancellation of scar formation, a process secondary to contraction. Contraction blocking by DRT is the result of a dramatic phenotype change in contractile cells (myofibroblasts, MFB) which follows specific binding of integrins α1β1 and α2β1 onto hexapeptide ligands, probably GFOGER and GLOGER, that are naturally present on the surface of collagen fibers in DRT. The methodology of organ regeneration based on use of DRT has been recently extended from traumatized skin to diseased skin. Successful extension of the method to other organs in which wounds heal by contraction is highly likely though not yet attempted. This regenerative paradigm is much more advanced both in basic mechanistic understanding and clinical use than methods based on tissue culture or stem cells. It is also largely free of risk and has shown decisively lower morbidity and lower cost than organ transplantation.
登录
查看更多内容
影响因子：
1.7
作者：
Barcot, Zoran;Inga, Dakovic Bacalja;Bacalja, Vedran
通讯作者：
Bacalja, Vedran
影响因子：
5.3
作者：
Chamberlain, LJ;Yannas, IV;Spector, M
通讯作者：
Spector, M
影响因子：
9.7
作者：
Grant, C. A.;Twigg, P. C.;Tobin, D. J.
通讯作者：
Tobin, D. J.
影响因子：
3.8
作者：
Choi, Heejin;Tzeranis, Dimitrios S.;So, Peter T. C.
通讯作者：
So, Peter T. C.
影响因子：
9.6
作者：
HUNTER, JAA;FINLAY, JB
通讯作者：
FINLAY, JB