Ranking the Leading Risk Factors for Sudden Unexpected Death in Epilepsy.
Ranking the Leading Risk Factors for Sudden Unexpected Death in Epilepsy.
复制标题
DOI：
10.3389/fneur.2017.00473
复制
发表时间：
2017
影响因子：
3.4
通讯作者：
Moseley BD
中科院分区：
文献类型：
--
作者：
DeGiorgio CM;Markovic D;Mazumder R;Moseley BD
癫痫突发意外死亡（SUDEP）在控制良好的癫痫中是罕见的。然而，SUDEP是耐药性癫痫的常见死因。在过去的30年里，多个队列和人群研究已经确定了与SUDEP风险增加相关的临床风险因素。从主要队列和基于人群的研究中识别和排名主要SUDEP风险因素。SUDEP的发生率也在特殊的临床情况下进行了评估，包括抗癫痫药物治疗、癫痫手术、器械和临床试验中分配给安慰剂。对1987 - 2017年期间的英语人类队列研究进行了PubMed检索，检索词为“突然”、“死亡”和“癫痫”。确定SUDEP的危险因素，并通过加权对数调整比值比（OR）/相对风险比（RR）进行排序。对数校正OR/RR从高到低排列的前10个主要危险因素依次为：每年GTC发作≥ 3次;过去一年内发作≥ 13次;未接受抗癫痫药物（AED）治疗; ≥ 3种AED;过去一年内GTC发作≥ 3次;过去3个月内GTC发作11 - 20次;发病年龄0 - 15岁; IQ <70;过去一年内AED变化3 - 5次; ≥ 3种AED。来自不同来源的两个风险因素（≥ 3次GTC发作和≥ 3次AED）在前10个风险因素中出现两次。确定了SUDEP的前10个风险因素并进行了排名。最高风险因素的排名可以帮助临床医生识别SUDEP风险最高的患者。
Sudden unexpected death in epilepsy (SUDEP) is rare in well-controlled epilepsy. However, SUDEP is a common cause of death in drug-resistant epilepsy. Over the last 30 years, multiple cohort and population studies have identified clinical risk factors associated with an increased risk for SUDEP. To identify and rank the leading SUDEP risk factors from major cohort and population-based studies. The incidence of SUDEP is also evaluated in special clinical situations, including antiepileptic drug treatment, epilepsy surgery, devices, and assignment to placebo in clinical trials. A PubMed search for English language human cohort studies for the terms Sudden, Death, and Epilepsy was performed for the years 1987–2017. Risk factors for SUDEP were identified and ranked by the weighted log adjusted odds ratio (OR)/relative risk ratio (RR). The top 10 leading risk factors ranked from highest to lowest log adjusted OR/RR are the following: ≥3 GTC seizures per year; ≥13 seizures in the last year; No Antiepileptic Drug (AED) treatment; ≥3 AEDs; ≥3 GTCs in the past year; 11–20 GTC seizures in the last 3 months; age of onset 0–15 years old; IQ < 70; 3–5 AED changes in the last year; ≥3 AEDs. Two risk factors from separate sources (≥3 GTC seizures and ≥3 AEDs) occur twice in the top 10 risk factors. The top 10 risk factors for SUDEP are identified and ranked. A ranking of the top risk factors could help clinicians identify patients at highest risk for SUDEP.
登录
查看更多内容
影响因子：
9.9
作者：
Ficker, DM;So, EL;Belau, PG
通讯作者：
Belau, PG
影响因子：
9.9
作者：
Mu, J.;Liu, L.;Zhou, D.
通讯作者：
Zhou, D.
影响因子：
168.9
作者：
Nilsson, L;Farahmand, BY;Tomson, T
通讯作者：
Tomson, T
影响因子：
5.6
作者：
Ryvlin, Philippe;Nashef, Lina;Tomson, Torbjorn
通讯作者：
Tomson, Torbjorn
影响因子：
3.4
作者：
Novak, Jennifer L.;Miller, Patrick R.;DeGiorgio, Christopher M.
通讯作者：
DeGiorgio, Christopher M.