Behavioral and Environmental Modification of the Genetic Influence on Body Mass Index: A Twin Study.
Behavioral and Environmental Modification of the Genetic Influence on Body Mass Index: A Twin Study.
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DOI：
10.1007/s10519-015-9718-6
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发表时间：
2015-07
影响因子：
2.6
通讯作者：
Duncan, Glen E.
中科院分区：
文献类型：
--
作者：
Horn, Erin E.;Turkheimer, Eric;Strachan, Eric;Duncan, Glen E.
身体质量指数（BMI）有很强的遗传基础，遗传率约为0.75，但也受到许多行为和环境因素的影响。建筑环境的各个方面（例如，环境步行性）被假设通过直接影响BMI、通过促进或抑制与BMI相关的行为如身体活动、或通过抑制向更高BMI的遗传倾向来影响肥胖。本研究使用5,079对同性成年双胞胎（70%为同卵双胞胎，65%为女性）调查了身体活动和步行能力对BMI变化的相对影响。高活动和步行水平独立抑制BMI的遗传变异。然而，同时估计它们的影响表明，步行影响是由活动介导的。即使低BMI个体倾向于选择需要更高活动水平的环境，活动对BMI变化的抑制作用也存在。总的来说，我们的研究结果指出，社区或宏观层面的干预措施，促进个人层面的行为，作为一个合理的方法来解决美国成年人的肥胖流行病。
Body mass index (BMI) has a strong genetic basis, with a heritability around 0.75, but is also influenced by numerous behavioral and environmental factors. Aspects of the built environment (e.g., environmental walkability) are hypothesized to influence obesity by directly affecting BMI, by facilitating or inhibiting behaviors such as physical activity that are related to BMI, or by suppressing genetic tendencies toward higher BMI. The present study investigated relative influences of physical activity and walkability on variance in BMI using 5,079 same-sex adult twin pairs (70% monozygotic, 65% female). High activity and walkability levels independently suppressed genetic variance in BMI. Estimating their effects simultaneously, however, suggested that the walkability effect was mediated by activity. The suppressive effect of activity on variance in BMI was present even with a tendency for low-BMI individuals to select into environments that require higher activity levels. Overall, our results point to community- or macro-level interventions that facilitate individual-level behaviors as a plausible approach to addressing the obesity epidemic among U.S. adults.
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影响因子：
7.6
作者：
BARON, RM;KENNY, DA
通讯作者：
KENNY, DA
影响因子：
158.5
作者：
BOUCHARD, C;TREMBLAY, A;FOURNIER, G
通讯作者：
FOURNIER, G
影响因子：
158.5
作者：
Cecil, Joanne E.;Tavendale, Roger;Palmer, Colin N. A.
通讯作者：
Palmer, Colin N. A.
对体育活动参与的独特环境影响：一项双胞胎研究。
影响因子：
3.7
作者：
Duncan, Glen E.;Goldberg, Jack;Noonan, Carolyn;Moudon, Anne Vernez;Hurvitz, Philip;Buchwald, Dedra
通讯作者：
Buchwald, Dedra
影响因子：
4.7
作者：
Cauchi, Stephane;Stutzmann, Fanny;Froguel, Philippe
通讯作者：
Froguel, Philippe