Increase in body mass index from normal weight to overweight in a cross-sectional sample of healthy research volunteers.
Increase in body mass index from normal weight to overweight in a cross-sectional sample of healthy research volunteers.
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DOI：
10.1016/j.nutres.2014.10.007
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发表时间：
2014-12
期刊：
影响因子：
--
通讯作者：
Zambell KL
中科院分区：
文献类型：
--
作者：
Courville AB;DiVito M;Moyer L;Rossinoff A;Royster C;Psota T;Ayres E;Zambell KL
目前的文献提供了有限的信息，健康志愿者作为对照的生物医学研究。本研究描述了美国国立卫生研究院临床中心（NIH CC）健康志愿者人群的体重指数（BMI）（体重与身高的比值（kg/m2））趋势，并将这些趋势与国家健康与营养调查（NHANES）报告的全国代表性样本进行了比较。我们假设NIH CC的BMI趋势将遵循美国人群的趋势。这项横断面研究检查了1976-80年，1981-87年，1988-94年，1995-98年以及随后两年直至2012年的NIH CC健康志愿者的BMI。研究数据来自NIH生物医学转化研究信息系统（BTRIS）。根据出院代码“志愿者”选择受试者。计算NIH CC志愿者的身高、体重、年龄校正BMI、年龄和性别的描述性统计量，并使用χ2检验分析分类变量之间的相关性。使用Kruskal-Wallis和事后Tamhane T2检验评估连续自变量的BMI类别或时间段之间的差异。13，898名健康志愿者的中位年龄为34岁，其中53%为女性，主要是非西班牙裔白人。1976-1987年的平均BMI在正常范围内。从1988年开始，平均BMI有所波动，但总体上有所增加。NIH CC的健康志愿者的BMI似乎遵循NHANES数据所描述的国家趋势，即在过去三十年中体重增加，然后是最近的平台期。
Current literature provides limited information about healthy volunteers serving as controls for biomedical research. This study describes trends in body mass index (BMI), a ratio of weight to height (kg/m2), of the population of healthy volunteers at the National Institutes of Health Clinical Center (NIH CC) and compares these trends to a nationally-representative sample as reported by the National Health and Nutrition Examination Survey (NHANES). We hypothesized that BMI trends at the NIH CC would follow those of the US population. This cross-sectional study examined the BMI of healthy volunteers at the NIH CC from 1976-80, 1981-87, 1988-94, 1995-98, and for all subsequent two-year periods onward until 2012. Study data were extracted from the NIH Biomedical Translational Research Information System (BTRIS). Subjects were selected based on a discharge code of “volunteer.” Descriptive statistics of volunteers at the NIH CC were calculated for height, weight, age-adjusted BMI, age, and gender, and associations between categorical variables were analyzed using the χ2-test. Differences between BMI categories or time periods for continuous independent variables were assessed using Kruskal-Wallis and post-hoc Tamhane T2 tests. The 13,898 healthy volunteers with median age of age 34 years were 53% female and primarily non-Hispanic whites. Mean BMI was within the normal category from 1976-1987. From 1988 on, mean BMI fluctuated, but increased overall. The BMI of healthy volunteers at the NIH CC appears to follow national trends as described by NHANES data of increasing body weight during the past three decades followed by a recent plateau.
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DOI：
10.1001/jama.2014.732
发表时间：
2014-02-26
期刊：
JAMA
影响因子：
--
作者：
Ogden CL;Carroll MD;Kit BK;Flegal KM
通讯作者：
Flegal KM
影响因子：
2.9
作者：
Almeida, Luis;Kashdan, Todd B.;Soares-da-Silva, Patricio
通讯作者：
Soares-da-Silva, Patricio
DOI：
10.1111/j.1365-2125.1995.tb04469.x
发表时间：
1995-04-01
影响因子：
3.4
作者：
FARRE, M;LAMAS, X;CAMI, J
通讯作者：
CAMI, J
影响因子：
7.2
作者：
Thomson, CA;Harris, RB;Ab, CAT
通讯作者：
Ab, CAT
影响因子：
--
作者：
Donato, KA;Pi-Sunyer, FX;Chiquette, E
通讯作者：
Chiquette, E