Serum factor-dependent resistance of Haemophilus influenzae type b to antibody to lipopolysaccharide.
Serum factor-dependent resistance of Haemophilus influenzae type b to antibody to lipopolysaccharide.
复制标题
b 型流感嗜血杆菌对脂多糖抗体的血清因子依赖性耐药性。
DOI：
10.1093/infdis/151.5.869
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
P. Anderson
中科院分区：
文献类型：
--
作者：
T. Inzana;P. Anderson
Haemophilus influenzae type b (Hib) grown in broth is much more sensitive to killing by antibody to lipopolysaccharide (LPS) and complement than is Hib in bacteremic rats; upon brief incubation with low-molecular-weight components of plasma or serum, however, broth-grown cells are phenotypically converted to a resistance resembling that in vivo. This conversion was found to consume a limiting factor in serum filtrate, to require protein synthesis, and to occur independently of the presence of capsule. Less antibody to LPS bound to cells of the resistant (Res) phenotype than to cells of the sensitive (Sen) phenotype. In electrophoretic analysis the mobility of LPS bands was identical, but the staining density of the LPS bands extracted from Res cells (with phenol-water) was two-to fourfold greater than from an equal number of Sen cells. A similar differential was found in an immunologic assay of LPS in the extracts. Thus, Hib in the Res phenotype (and perhaps Hib in vivo) contains more LPS than Hib in the Sen phenotype, but its LPS appears less accessible to antibody.
b 型流感嗜血杆菌脑膜炎后人体抗体对脂多糖的反应。
DOI：
10.1093/infdis/145.2.181
发表时间：
1982
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Shenep,JL;MunsonJr,RS;Granoff,DM
通讯作者：
Granoff,DM
流感嗜血杆菌疾病分离株的外膜蛋白组成：致病性和流行病学意义。
影响因子：
3.1
作者：
Loeb,MR;Smith,DH
通讯作者：
Smith,DH
b 型流感嗜血杆菌的多糖-蛋白质复合物。
DOI：
10.1093/infdis/144.6.521
发表时间：
1981
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Insel,RA;Anderson,P;Loeb,MR;Smith,DH
通讯作者：
Smith,DH