Sleep enhances reconsolidation-based strengthening of visuospatial memories.
Sleep enhances reconsolidation-based strengthening of visuospatial memories.
复制标题
睡眠可增强基于重新巩固的视觉空间记忆强化。
DOI：
10.1038/s41598-022-11135-6
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发表时间：
2022-05-04
影响因子：
4.6
通讯作者：
中科院分区：
文献类型：
--
作者：
强化记忆在重新激活时可以恢复到不稳定状态。重新激活的记忆的重新稳定或重新巩固可以允许先前建立的记忆发生变化。鉴于睡眠在记忆最初巩固中的作用，睡眠可能对重新巩固也很重要。然而，睡眠对再巩固的影响以及可能起作用的睡眠的具体方面尚不清楚。在这里，参与者学习了30个图片-位置对。过夜睡眠后，测试初始巩固。在一天（实验1）或一周（实验2）之后，参与者再次接受测试以重新激活他们的记忆，然后学习30个新的图片-位置对。对照组（实验1）在新的学习之前没有重新激活。12小时后，在白天清醒或过夜睡眠后，参与者完成了最后的记忆测试。睡眠参与者在重新激活和最终测试之间进行多导睡眠描记。在实验1中，与没有再激活相比，再激活导致记忆的保存。与清醒时相比，睡眠与再激活后记忆下降的相关性更小，记忆保存与非快速眼动睡眠时间呈正相关。在实验2中，睡眠与更大的再激活后的记忆改善比清醒，改善正相关的西格玛活动。这些结果表明，睡眠增强了基于再巩固的情景记忆强化。
Consolidated memories can be returned to a labile state upon reactivation. The re-stabilization of reactivated memories, or reconsolidation, can allow for change in previously established memories. Given the role of sleep in the initial consolidation of memories, sleep may be important for reconsolidation as well. However, effects of sleep on reconsolidation and specific aspects of sleep that may contribute are unclear. Here, participants learned 30 picture-location pairs. After overnight sleep, initial consolidation was tested. Following either one day (Experiment 1) or one week (Experiment 2), participants were tested again to reactivate their memory and then learned 30 novel picture-location pairs. Control groups (Experiment 1) received no reactivation prior to new learning. Twelve hours later, after daytime wakefulness or overnight sleep, participants completed a final memory test. Sleep participants underwent polysomnography between reactivation and final tests. In Experiment 1, reactivation led to preservation of memory compared to no reactivation. Sleep was associated with less post-reactivation memory decline than waking, with memory preservation positively related to time spent in non-rapid-eye movement sleep. In Experiment 2, sleep was associated with greater post-reactivation memory improvement than waking, with improvement positively related to sigma activity. These results suggest sleep enhances reconsolidation-based strengthening of episodic memories.
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影响因子：
19.9
作者：
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通讯作者：
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影响因子：
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通过重新整合通过检索来增强恐惧记忆。
影响因子：
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通讯作者：
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