Vitamin E intake and risk of esophageal and gastric cancers in the NIH-AARP Diet and Health Study.
Vitamin E intake and risk of esophageal and gastric cancers in the NIH-AARP Diet and Health Study.
复制标题
DOI：
10.1002/ijc.24342
复制
发表时间：
2009-07-01
影响因子：
6.4
通讯作者：
Abnet CC
中科院分区：
文献类型：
--
作者：
Carman S;Kamangar F;Freedman ND;Wright ME;Dawsey SM;Dixon LB;Subar A;Schatzkin A;Abnet CC
我们调查了饮食中α-生育酚、γ-生育酚和补充维生素E摄入与食管鳞状细胞癌风险的关系（ESCC; n = 158），食管腺癌（EAC; n = 382），贲门腺癌（GCA; n = 320）和胃非贲门腺癌（GNCA; n = 327）。在基线时使用经验证的问卷收集饮食和补充维生素E摄入量数据，并使用考克斯回归模型进行分析。摄入量作为连续变量和四分位数进行分析。对于膳食α-生育酚，我们在连续分析中发现了一些与ESCC降低和EAC风险增加相关的证据，每增加1.17 mg（四分位数范围的一半），校正的风险比（HR）和95%置信区间（CI）分别为0.90（0.81 - 0.99）和1.05（1.00 - 1.11）。然而，在四分位数分析中，这两种癌症的趋势p值均不显著。膳食α-生育酚与GCA或GNCA之间没有关联。我们观察到与γ-生育酚无统计学显著相关性。对于补充维生素E，结果基本为零，除了补充更高剂量的维生素E显著降低GNCA的风险。补充维生素E增加71 mg/天（四分位数范围的一半）的HR（95% CI）为0.92（0.85-1.00），四分位数分析中趋势的p值为0.015。
We investigated the association of dietary α-tocopherol, γ-tocopherol, and supplemental vitamin E intake with the risk of esophageal squamous cell carcinoma (ESCC; n = 158), esophageal adenocarcinoma (EAC; n = 382), gastric cardia adenocarcinoma (GCA; n = 320), and gastric noncardia adenocarcinoma (GNCA; n = 327) in the NIH-AARP Diet and Health Study, a cohort of approximately 500,000 people. Data on dietary and supplemental vitamin E intake were collected using a validated questionnaire at baseline and were analyzed using Cox regression models. Intakes were analyzed as continuous variables and as quartiles. For dietary α-tocopherol, we found some evidence of association with decreased ESCC and increased EAC risk in the continuous analyses, with adjusted hazard ratios (HR) and 95% confidence intervals (CI) of 0.90 (0.81 – 0.99) and 1.05 (1.00 – 1.11), respectively, per 1.17 mg (half the interquartile range) increased intake. However, in quartile analyses, the p-value for trend was non-significant for both of these cancers. There was no association between dietary α-tocopherol and GCA or GNCA. We observed no statistically significant associations with γ-tocopherol. For supplemental vitamin E, the results were mainly null, except for a significantly lower risk of GNCA with higher doses of supplemental vitamin E. An increase of 71 mg/day (half the interquartile range) in supplemental vitamin E had an HR (95% CI) of 0.92 (0.85–1.00) and the p-value for trend in the quartile analyses was 0.015.
登录
查看更多内容
DOI：
10.1093/jnci/djg044
发表时间：
2003-09-17
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Taylor, PR;Qiao, YL;Mark, SD
通讯作者：
Mark, SD
影响因子：
4.2
作者：
Mayne, ST
通讯作者：
Mayne, ST
DOI：
10.1007/s00432-002-0380-z
发表时间：
2002-10-01
影响因子：
3.6
作者：
Bollschweiler, E;Wolfgarten, E;Hölscher, AH
通讯作者：
Hölscher, AH
影响因子：
2.9
作者：
Chen, HL;Tucker, KL;Ward, MH
通讯作者：
Ward, MH
影响因子：
3.8
作者：
Nouraie, M;Pietinen, P;Taylor, PR
通讯作者：
Taylor, PR