Dim artificial light at night alters immediate early gene expression throughout the avian brain.
Dim artificial light at night alters immediate early gene expression throughout the avian brain.
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DOI：
10.3389/fnins.2023.1194996
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发表时间：
2023
影响因子：
4.3
通讯作者：
Ouyang, Jenny Q.
中科院分区：
文献类型：
--
作者：
Hui, Cassandra K.;Chen, Nadya;Chakraborty, Arunima;Alaasam, Valentina;Pieraut, Simon;Ouyang, Jenny Q.
夜间人造光（ALAN）是一种普遍存在的污染物，会改变生理和行为。然而，触发这些变化的潜在机制尚不清楚，因为以前的工作表明，ALAN的暗淡水平可能具有掩蔽效应，绕过中央时钟。光刺激许多大脑区域的神经元活动，这反过来又可以激活调节生理反应的下游效应器。在本研究中，利用立即早期基因（IEG）表达作为神经元活动的代理，我们确定了响应ALAN激活的脑区。我们将斑胸草雀暴露在昏暗的ALAN（1.5勒克斯）中，并分析了整个大脑的24个区域。我们发现，暴露于ALAN的鸟类中两种不同的IEGs，cFos和ZENK的总体表达与夜间不活动的鸟类有显著差异。此外，我们发现，在与视觉、运动、学习和记忆、疼痛处理和激素调节相关的几个脑区中，暴露于ALAN的鸟类与夜间不活动和白天活动的鸟类具有显著不同的IEG表达。这些结果提供了深入了解的机制途径，响应ALAN的基础下游，有据可查的行为和生理变化。
Artificial light at night (ALAN) is a pervasive pollutant that alters physiology and behavior. However, the underlying mechanisms triggering these alterations are unknown, as previous work shows that dim levels of ALAN may have a masking effect, bypassing the central clock. Light stimulates neuronal activity in numerous brain regions which could in turn activate downstream effectors regulating physiological response. In the present study, taking advantage of immediate early gene (IEG) expression as a proxy for neuronal activity, we determined the brain regions activated in response to ALAN. We exposed zebra finches to dim ALAN (1.5 lux) and analyzed 24 regions throughout the brain. We found that the overall expression of two different IEGs, cFos and ZENK, in birds exposed to ALAN were significantly different from birds inactive at night. Additionally, we found that ALAN-exposed birds had significantly different IEG expression from birds inactive at night and active during the day in several brain areas associated with vision, movement, learning and memory, pain processing, and hormone regulation. These results give insight into the mechanistic pathways responding to ALAN that underlie downstream, well-documented behavioral and physiological changes.
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影响因子：
3.7
作者：
Feenders, Gesa;Liedvogel, Miriam;Rivas, Miriam;Zapka, Manuela;Horita, Haruhito;Hara, Erina;Wada, Kazuhiro;Mouritsen, Henrik;Jarvis, Erich D.
通讯作者：
Jarvis, Erich D.
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Zhang, Zhi
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作者：
El-Sherif, Y;Tesoriero, J;Wieraszko, A
通讯作者：
Wieraszko, A
影响因子：
10.3
作者：
Chabot, V;Caldani, M;Pelletier, J
通讯作者：
Pelletier, J