Vitamin D metabolism and innate immunity.
Vitamin D metabolism and innate immunity.
复制标题
DOI：
10.1016/j.mce.2011.04.015
复制
发表时间：
2011-12-05
影响因子：
4.1
通讯作者：
Hewison, Martin
中科院分区：
文献类型：
--
作者：
Lagishetty, Venu;Liu, Nancy Q.;Hewison, Martin
维生素D对免疫系统的影响已经被认识了三十多年，部分源于对与肉芽肿性疾病相关的维生素D代谢失调的分析。然而，只是在最近几年，维生素D和正常免疫功能之间的相互作用才被提出。与最初的研究一样，这种关于维生素D免疫调节的新观点的基础源于免疫细胞对维生素D代谢的研究。特别是，通过病原体识别受体诱导单核细胞中的维生素D激活酶CYP 27 B1，突出了维生素D作为抗菌先天免疫应答的有效诱导剂的全新功能。这促使维生素D在保护广泛组织免受感染方面发挥新的潜在作用，但也促使对适当维生素D状态的参数进行修订。以下综述描述了维生素D先天免疫应答的一些关键进展，特别强调了关键代谢酶作为维生素D局部免疫活性决定因素的作用。
Effects of vitamin D on the immune system have been recognized for over thirty years and stemmed in part from analysis of the dysregulated vitamin D metabolism associated with granulomatous diseases. However, it is only in more recent years that a role for interaction between vitamin D and normal immune function has been proposed. As with the original studies, the basis for this new perspective on immunmodulation by vitamin D stems from studies of vitamin D metabolism by immune cells. In particular, induction of the vitamin D-activating enzyme CYP27B1 in monocytes via pathogen recognizing receptors has highlighted an entirely new function for vitamin D as a potent inducer of antibacterial innate immune responses. This has prompted a new potential role for vitamin D in protecting against infection in a wide range of tissues but has also prompted revision of the parameters for adequate vitamin D status. The following review describes some of the key developments in innate immune responses to vitamin D with particular emphasis on the role of key metabolic enzyme as determinants of localized immune activity of vitamin D.
登录
查看更多内容
DOI：
10.1084/jem.175.4.1111
发表时间：
1992-04-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Chan J;Xing Y;Magliozzo RS;Bloom BR
通讯作者：
Bloom BR
影响因子：
158.5
作者：
BARBOUR, GL;COBURN, JW;HORST, RL
通讯作者：
HORST, RL
影响因子：
4.4
作者：
Boonstra, A;Barrat, FJ;O'Garra, A
通讯作者：
O'Garra, A
DOI：
10.1073/pnas.80.18.5583
发表时间：
1983-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
ABE, E;MIYAURA, C;SUDA, T
通讯作者：
SUDA, T
DOI：
10.1073/pnas.78.8.4990
发表时间：
1981-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
ABE, E;MIYAURA, C;SUDA, T
通讯作者：
SUDA, T