Influenza enhances susceptibility to natural acquisition of and disease due to Streptococcus pneumoniae in ferrets.
Influenza enhances susceptibility to natural acquisition of and disease due to Streptococcus pneumoniae in ferrets.
复制标题
DOI：
10.1086/656333
复制
发表时间：
2010-10-15
期刊：
影响因子：
--
通讯作者：
Henriques Normark B
中科院分区：
文献类型：
--
作者：
McCullers JA;McAuley JL;Browall S;Iverson AR;Boyd KL;Henriques Normark B
呼吸道病毒在肺炎链球菌传播中的作用尚不清楚。诸如哪种血清型最适合传播和疾病，以及流感病毒是否以血清型特异性方式改变这些参数等关键问题尚未得到充分研究。在一种新的雪貂传播模型中，我们证明了供体先前感染流感病毒会增强肺炎球菌的传播和疾病。洗鼻细菌滴度、粘膜和侵袭性疾病的发病率以及接触者感染的百分比均有所增加。接触性雪貂的病毒感染在感染百分比和感染距离上都增加了其易感性。这些流感介导的对定植、传播和疾病的影响是肺炎球菌菌株依赖的。总的来说，这些数据表明，呼吸道病毒感染、肺炎球菌感染和疾病发展之间关系的人类研究需要进一步研究才能更好地理解。
The role of respiratory viruses in transmission of Streptococcus pneumoniae is poorly understood. Key questions such as which serotypes are most fit for transmission and disease, and whether influenza virus alters these parameters in a serotype specific manner have not been adequately studied. In a novel model of ferret transmission, we demonstrated that prior infection with influenza virus of donors enhanced pneumococcal transmission and disease. Nasal wash bacterial titers, the incidence of mucosal and invasive disease, and the percentage of contacts infected were all increased. Viral infection of contact ferrets increased their susceptibility to acquisition both in terms of percentage infected and distance over which they could acquire infection. These influenza mediated effects on colonization, transmission and disease were pneumococcal strain dependent. Overall, these data argue that human studies of the relationship between respiratory viral infections, acquisition of pneumococci, and development of disease need further study to be better understood.
登录
查看更多内容
影响因子：
11.8
作者：
Regev-Yochay, G;Raz, M;Rubinstein, E
通讯作者：
Rubinstein, E
影响因子：
3.6
作者：
GRAY, BM;DILLON, HC
通讯作者：
DILLON, HC
影响因子：
6.4
作者：
Sandgren, A;Sjöström, K;Normark, BH
通讯作者：
Normark, BH
影响因子：
6.4
作者：
McCullers, JA;Bartmess, KC
通讯作者：
Bartmess, KC
影响因子：
6.4
作者：
GRAY, BM;CONVERSE, GM;DILLON, HC
通讯作者：
DILLON, HC