Multiple Roles for B-Lymphocytes in Sjogren's Syndrome.
Multiple Roles for B-Lymphocytes in Sjogren's Syndrome.
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DOI:
10.3390/jcm5100087
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发表时间:
2016-10-08
影响因子:
3.9
通讯作者:
Peck A
中科院分区:
文献类型:
--
作者:
Ambrus JL;Suresh L;Peck A
Sjogren’s syndrome (SS) is a complex heterogeneous autoimmune disease resulting in loss of salivary gland and lacrimal gland function that may include multiple systemic manifestations including lymphoma. Multiple cell types participate in disease pathogenesis. This review discusses evidence for abnormal B cell subpopulations in patients with SS, critical roles of B cells in SS and the status of B cell–directed therapies in the management of patients with SS.
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