Multiple Roles for B-Lymphocytes in Sjogren's Syndrome.

Multiple Roles for B-Lymphocytes in Sjogren's Syndrome.
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DOI:
10.3390/jcm5100087
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发表时间:
2016-10-08
影响因子:
3.9
通讯作者:
Peck A
Peck A
中科院分区:
医学2区
文献类型:
--
作者:
Ambrus JL;Suresh L;Peck A

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干燥综合征(SS)是一种复杂的异质性自身免疫性疾病,导致唾液腺和泪腺功能丧失,可能包括多种全身表现,包括淋巴瘤。多种细胞类型参与疾病的发病机制。本文综述了SS患者B细胞亚群异常的证据、B细胞在SS中的关键作用以及B细胞导向治疗在SS患者治疗中的地位。
Sjogren’s syndrome (SS) is a complex heterogeneous autoimmune disease resulting in loss of salivary gland and lacrimal gland function that may include multiple systemic manifestations including lymphoma. Multiple cell types participate in disease pathogenesis. This review discusses evidence for abnormal B cell subpopulations in patients with SS, critical roles of B cells in SS and the status of B cell–directed therapies in the management of patients with SS.
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