Racial and ethnic disparities in colorectal cancer incidence and mortality.
Racial and ethnic disparities in colorectal cancer incidence and mortality.
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DOI：
10.1016/bs.acr.2021.02.007
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发表时间：
2021
影响因子：
--
通讯作者：
Carethers, John M.
中科院分区：
文献类型：
--
作者：
Carethers, John M.
结直肠癌（CRC）的发生在美国公认的种族和民族之间存在很大的差异，其中美国黑人的发病率和死亡率最高。观察到的CRC差异的贡献者似乎是多因素的，可能是由结构化的社会问题引发的（例如社会经济地位低和缺乏足够的健康保险），促进异常环境因素（通过使用烟草和酒精，以及改变新陈代谢的不良饮食组成，微生物群和局部免疫微环境）并触发癌症特异性免疫和遗传变化（例如局部炎症和体细胞驱动基因突变）。通过CRC筛查进行预防可缓解差异，但一旦CRC发生，这一点尚未得到充分证明。获得更多的知识，了解观察到的差异背后的科学，将为减少美国种族和民族之间CRC的发病率和死亡率提供信息。
The occurrence of colorectal cancer (CRC) shows a large disparity among recognized races and ethnicities in the U.S., with Black Americans demonstrating the highest incidence and mortality from this disease. Contributors for the observed CRC disparity appear to be multifactorial and consequential that may be initiated by structured societal issues (e.g. low socioeconomic status and lack of adequate health insurance) that facilitate abnormal environmental factors (through use of tobacco and alcohol, and poor diet composition that modifies one’s metabolism, microbiome and local immune microenvironment) and trigger cancer-specific immune and genetic changes (e.g. localized inflammation and somatic driver gene mutations). Mitigating the disparity by prevention through CRC screening has been demonstrated; this has not been adequately shown once CRC has developed. Acquiring additional knowledge into the science behind the observed disparity will inform approaches towards abating both the incidence and mortality of CRC between U.S. racial and ethnic groups.
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影响因子：
11.1
作者：
Carethers, J. M.
通讯作者：
Carethers, J. M.
影响因子：
10.5
作者：
Brennan CA;Garrett WS
通讯作者：
Garrett WS
影响因子：
3.7
作者：
Carethers, John M.;Murali, Bhavya;McGuire, Kathleen L.
通讯作者：
McGuire, Kathleen L.
影响因子：
39.2
作者：
Brenner, Hermann;Chang-Claude, Jenny;Hoffmeister, Michael
通讯作者：
Hoffmeister, Michael
影响因子：
3.1
作者：
Ashktorab, Hassan;Sherif, Zaki;Brim, Hassan
通讯作者：
Brim, Hassan