Emergence of dormant conditioned incentive approach by conditioned withdrawal in nicotine addiction.
Emergence of dormant conditioned incentive approach by conditioned withdrawal in nicotine addiction.
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DOI：
10.1016/j.biopsych.2010.05.017
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发表时间：
2010-10-15
影响因子：
10.6
通讯作者：
Hiroi, Noboru
中科院分区：
文献类型：
--
作者：
Scott, Daniel;Hiroi, Noboru
关键词：
尼古丁是持续吸烟的决定因素之一，这种适应不良行为的特点是许多症状，包括戒断和寻求尼古丁。人们对戒断影响尼古丁寻求的过程知之甚少。在雄性 C57BL/6J 小鼠（n = 8 - 17/组）中评估了戒断相关线索对尼古丁 (0.2 mg/kg) 条件位置偏好 (CPP) 的影响。为了建立一个与戒断相关的选择性线索，与尼古丁相关的线索不同，在他们的笼子里将一个音调与戒断配对；小鼠在家笼中通过饮用水长期暴露于尼古丁（200 μg/mL，持续 15 天），并接受烟碱乙酰胆碱受体拮抗剂美加明（2.5 mg/kg）以在有声音的情况下加速戒断。然后，当尼古丁 CPP 自发消失时，在位置调节装置中评估与戒断相关的音调对尼古丁 CPP 的影响。与突然戒断相关的提示重新激活了尼古丁相关提示对 CPP 的休眠作用。这种效应发生在持续接触尼古丁期间，但在戒烟期间不会。条件性戒断线索可以直接放大与尼古丁相关的线索的激励特性。这一观察结果将当代关于戒断在成瘾中的作用的激励解释扩展到提示-提示相互作用。
Nicotine is one of the determinants for the development of persistent smoking and this maladaptive behavior is characterized by many symptoms, including withdrawal and nicotine seeking. The process by which withdrawal affects nicotine seeking is poorly understood. The impact of a withdrawal-associated cue on nicotine (0.2 mg/kg) conditioned place preference (CPP) was assessed in male C57BL/6J mice (n = 8 - 17/group). To establish a cue selectively associated with withdrawal distinct from those associated with nicotine, a tone was paired with withdrawal in their home cages; mice were chronically exposed to nicotine (200 μg/mL for 15 d) in their home cages from drinking water, and received the nicotinic acetylcholine receptor antagonist mecamylamine (2.5 mg/kg) to precipitate withdrawal in the presence of a tone. The effect of the withdrawal-associated tone on nicotine CPP was then evaluated in the place conditioning apparatus after a delay, when nicotine CPP spontaneously disappeared. A cue associated with precipitated withdrawal reactivated the dormant effect of nicotine-associated cues on CPP. This effect occurred during continuous exposure to nicotine, but not during abstinence. A conditioned withdrawal cue could directly amplify the incentive properties of cues associated with nicotine. This observation extends the contemporary incentive account of the role of withdrawal in addiction to cue-cue interaction.
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影响因子：
3.4
作者：
CORRIGALL, WA;COEN, KM
通讯作者：
COEN, KM
影响因子：
2.3
作者：
Carter, BL;Tiffany, ST
通讯作者：
Tiffany, ST
影响因子：
11
作者：
Hiroi N;Scott D
通讯作者：
Scott D
影响因子：
3.4
作者：
Harvey, DM;Yasar, S;Goldberg, SR
通讯作者：
Goldberg, SR
DOI：
10.1080/14622200020032051
发表时间：
2001-02-01
期刊：
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
影响因子：
--
作者：
Cox, L S;Tiffany, S T;Christen, A G
通讯作者：
Christen, A G