Clinicopathological characteristics of mucinous carcinoma of the breast in Korea: comparison with invasive ductal carcinoma-not otherwise specified.
Clinicopathological characteristics of mucinous carcinoma of the breast in Korea: comparison with invasive ductal carcinoma-not otherwise specified.
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DOI：
10.3346/jkms.2010.25.3.361
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发表时间：
2010-03
影响因子：
4.5
通讯作者：
Lee KS
中科院分区：
文献类型：
--
作者：
Park S;Koo J;Kim JH;Yang WI;Park BW;Lee KS
比较粘液癌（MC）和浸润性导管癌（IDC-NOS）的临床病理特征和预后因素。回顾性分析104例MC患者的临床病理特征和生存情况，并与3，936例IDC-NOS进行比较。MC和IDC-NOS的诊断年龄中位数分别为45岁和47岁。钼靶X线和超声诊断单纯MC的敏感性分别为76.5%和94.7%。MC具有淋巴结转移少、分期低、雌激素受体表达高、HER-2过表达少、分化程度低等特点，其10年无病生存率（DFS）和总生存率（OS）分别为86.1%和86.3%，优于IDC-NOS（DFS和OS分别为74.7%和74.9%）。单纯型和混合型10年无瘤生存率分别为90.2%和68.8%。淋巴结状态和分期是影响生存率的统计学显著因素。MC在韩国人表现出类似的功能，西方人群除了发病年龄比IDC-NOS年轻。由于只有单纯MC的预后比IDC-NOS好，因此区分混合MC和单纯MC是很重要的。中年韩国妇女出现乳房症状应仔细检查，并进行适当的诊断评估，因为有些患者存在放射学良性病变。
Clinicopathological characteristics and prognostic factors of mucinous carcinoma (MC) were compared with invasive ductal carcinoma-not otherwise specified (IDC-NOS). Clinicopathological characteristics and survivals of 104 MC patients were retrospectively reviewed and compared with those of 3,936 IDC-NOS. The median age at diagnosis was 45 yr in MC and 47 yr in IDC-NOS, respectively. The sensitivity of mammography and sonography for pure MC were 76.5% and 94.7%, respectively. MC showed favorable characteristics including less involvement of lymph node, lower stage, more expression of estrogen receptors, less HER-2 overexpression and differentiated grade, and better 10-yr disease-free survival (DFS) and overall survival (OS) (86.1% and 86.3%, respectively) than IDC-NOS (74.7% and 74.9%, respectively). Ten-year DFS of pure and mixed type was 90.2% and 68.8%, respectively. Nodal status and stage were statistically significant factors for survival. MC in Koreans showed similar features to Western populations except for a younger age of onset than in IDC-NOS. Since only pure MC showed better prognosis than IDC-NOS, it is important to differentiate mixed MC from pure MC. Middle-aged Korean women presenting breast symptoms should be examined carefully and evaluated with an appropriate diagnostic work-up because some patients present radiologically benign-like lesions.
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影响因子：
3
作者：
Komenaka, IK;El-Tamer, MB;Schnabel, FR
通讯作者：
Schnabel, FR
影响因子：
8.8
作者：
Li, CI;Uribe, DJ;Daling, JR
通讯作者：
Daling, JR
影响因子：
2.6
作者：
Dhillon, R;Depree, P;Wylie, E
通讯作者：
Wylie, E
影响因子：
5
作者：
Houssami, N;Irwig, L;Noakes, J
通讯作者：
Noakes, J
DOI：
10.1007/bf02967190
发表时间：
2000-01-01
期刊：
Breast cancer (Tokyo, Japan)
影响因子：
--
作者：
Matsuda, M;Yoshimoto, M;Sakamoto, G
通讯作者：
Sakamoto, G