FTO affects food cravings and interacts with age to influence age-related decline in food cravings.
FTO affects food cravings and interacts with age to influence age-related decline in food cravings.
复制标题
DOI：
10.1016/j.physbeh.2017.12.013
复制
发表时间：
2018-08-01
影响因子：
2.9
通讯作者：
Zald DH
中科院分区：
文献类型：
--
作者：
Dang LC;Samanez-Larkin GR;Smith CT;Castrellon JJ;Perkins SF;Cowan RL;Claassen DO;Zald DH
脂肪量和肥胖相关基因（FTO）是全基因组关联研究发现的第一个与较高的体重指数（BMI）和肥胖几率增加相关的基因。FTO仍然是对体重影响最大和最重复的位点，但FTO影响体重和肥胖发展的机制尚未完全了解。在这里，我们测试了FTO是否与食物渴望的差异以及多巴胺功能的一个关键方面有关，该功能被假设影响食物奖励机制。此外，众所周知，食物渴望和多巴胺功能会随着年龄的增长而下降，我们探讨了年龄对FTO与食物渴望和多巴胺功能之间关系的影响。22 - 83岁的7 - 8名健康受试者完成了食物渴望问卷，并进行了FTO rs 9939609基因分型，这是第一个与肥胖相关的FTO单核苷酸多态性。与TT纯合子相比，携带肥胖易感A等位基因的个体具有更高的总食物渴望，这与更高的BMI相关。此外，食物渴望随着年龄的增长而下降，但这种年龄效应在FTO rs 9939609变体之间存在差异：虽然TT纯合子表现出典型的年龄相关的食物渴望下降，但A携带者中没有这种下降。所有受试者都用[18F]fallypride PET扫描，以评估最近的一项提议，即在神经化学水平上，FTO改变多巴胺D2样受体（DRD 2）功能，从而影响食物奖励相关机制。然而，我们没有观察到FTO对DRD 2可用性的影响。
The fat mass and obesity associated gene (FTO) was the first gene identified by genome-wide association studies to correlate with higher body mass index (BMI) and increased odds of obesity. FTO remains the locus with the largest and most replicated effect on body weight, but the mechanism whereby FTO affects body weight and the development of obesity is not fully understood. Here we tested whether FTO is associated with differences in food cravings and a key aspect of dopamine function that has been hypothesized to influence food reward mechanisms. Moreover, as food cravings and dopamine function are known to decline with age, we explored effects of age on relations between FTO and food cravings and dopamine function. Seven-eight healthy subjects between 22 and 83 years old completed the Food Cravings Questionnaire and underwent genotyping for FTO rs9939609, the first FTO single nucleotide polymorphism associated with obesity. Compared to TT homozygotes, individuals carrying the obesity-susceptible A allele had higher total food cravings, which correlated with higher BMI. Additionally, food cravings declined with age, but this age effect differed across variants of FTO rs9939609: while TT homozygotes showed the typical age-related decline in food cravings, there was no such decline among A carriers. All subjects were scanned with [18F]fallypride PET to assess a recent proposal that at the neurochemical level FTO alters dopamine D2-like receptor (DRD2) function to influence food reward related mechanisms. However, we observed no evidence of FTO effects on DRD2 availability.
登录
查看更多内容
影响因子：
40.5
作者：
Loos, Ruth J. F.;Yeo, Giles S. H.
通讯作者：
Yeo, Giles S. H.
影响因子：
3.3
作者：
CAMPS, M;CORTES, R;PALACIOS, JM
通讯作者：
PALACIOS, JM
影响因子：
5.4
作者：
Franken, IHA;Muris, P
通讯作者：
Muris, P
影响因子：
4.2
作者：
Karrer TM;Josef AK;Mata R;Morris ED;Samanez-Larkin GR
通讯作者：
Samanez-Larkin GR
影响因子：
56.9
作者：
Frayling, Timothy M.;Timpson, Nicholas J.;McCarthy, Mark I.
通讯作者：
McCarthy, Mark I.