Electroacupuncture Suppressed Neuronal Apoptosis and Improved Cognitive Impairment in the AD Model Rats Possibly via Downregulation of Notch Signaling Pathway.
Electroacupuncture Suppressed Neuronal Apoptosis and Improved Cognitive Impairment in the AD Model Rats Possibly via Downregulation of Notch Signaling Pathway.
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电针可能通过下调 Notch 信号通路抑制 AD 模型大鼠的神经元凋亡并改善认知障碍
DOI：
10.1155/2015/393569
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Cui GH
中科院分区：
文献类型：
--
作者：
Guo HD;Tian JX;Zhu J;Li L;Sun K;Shao SJ;Cui GH
针刺治疗阿尔茨海默病是一种潜在的治疗策略，其可能的作用机制值得进一步探讨。本研究提出并验证了Notch信号通路是否参与电针效应的假说。电针百会穴和肾俞穴组大鼠潜伏期短，在原平台象限停留时间长，穿越原平台象限次数多。电针可通过上调Bcl-2的表达和下调Bax的表达，减轻Aβ灌注所致的海马CA 1区细胞凋亡。电针可进一步明显促进海马突触素1和突触体素的表达。Aβ注射显著增加海马Notch 1、Jag 1和Hes 1 mRNA的表达，而EA处理则下调海马Notch 1和Hes 1 mRNA的水平，但对Jag 1 mRNA的表达无影响。提示电针可通过下调Notch信号通路改善AD大鼠的学习记忆功能。
Acupuncture is a potential strategy for the treatment of Alzheimer's disease (AD) and the possible mechanisms worth to be explored. In this study, we proposed and tested the hypothesis that whether Notch signaling pathway is involved in the effect of electroacupuncture (EA) treatment. Rats that received EA treatment on the acupoints of Baihui (Du 20) and Shenshu (BL 23) had shorter latency and remained in the original platform quadrant longer and crossed the former platform contained quadrant more frequently compared to the Aβ injection rats without EA treatment. EA obviously alleviated the cell apoptosis resulted by Aβ infusion in hippocampus CA1 regions through upregulating the expression of Bcl-2 and downregulating the expression of Bax. EA could further obviously promote the expression of synapsin-1 and synaptophysin in hippocampus. Aβ injection significantly increased the expression of Notch1, Jag1, and Hes1 mRNA, while EA treatment downregulated the level of Notch1 and Hes1 mRNA in hippocampus, but not Jag1 mRNA. Our data suggested that EA treatment improved learning and memory function in the AD rat model partially through downregulating Notch signaling pathway.
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