Effect of fibrinogen on blood coagulation detected by optical coherence tomography
Effect of fibrinogen on blood coagulation detected by optical coherence tomography
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光学相干断层扫描检测纤维蛋白原对凝血的影响
DOI：
10.1088/0031-9155/60/10/4185
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发表时间：
2015-05
影响因子：
3.5
通讯作者：
Xiangshuai Teng
中科院分区：
文献类型：
--
作者：
Xiangqun Xu;Xiangshuai Teng
Our previous work demonstrated that an optical coherence tomography (OCT) technique and the parameter 1/e light penetration depth (d1/e) were able to characterize the whole blood coagulation process in contrast to existing optical tests that are performed on plasma samples. To evaluate the feasibility of the technique for quantifying the effect of fibrinogen (Fbg) on blood coagulation, a dynamic study of d1/e of blood in various Fbg concentrations was performed in static state. Two groups of blood samples of hematocrit (HCT) in 35, 45, and 55% were reconstituted of red blood cells with: 1) treated plasma with its intrinsic Fbg removed and commercial Fbg added (0–8 g L−1); and 2) native plasma with commercial Fbg added (0–8 g L−1). The results revealed a typical behavior due to coagulation induced by calcium ions and the clotting time is Fbg concentration-dependent. The clotting time was decreased by the increasing amount of Fbg in both groups. Besides, the blood of lower HCT with various levels of Fbg took shorter time to coagulate than that of higher HCT. Consequently, the OCT method is a useful and promising tool for the detection of blood-coagulation processes induced with different Fbg levels.
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影响因子：
1.7
作者：
Yue Xiu-Li;Ma Fang;Dai Zhi-Fei
通讯作者：
Dai Zhi-Fei
DOI：
10.1002/9781444306286
发表时间：
2010-05
期刊：
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影响因子：
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N. Key;M. Makris;D. O'Shaughnessy;D. Lillicrap
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作者：
Erik A. Scott;K. Puca;Jennifer Heraly;J. Gottschall;K. Friedman
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使用光学相干断层扫描表征不同纤维蛋白原水平下的流动血液光学特性
影响因子：
4.6
作者：
Fu, Feifei;Xu, Xiangqun;Geng, Jinhai
通讯作者：
Geng, Jinhai
影响因子：
2.8
作者：
Kume, T;Akasaka, T;Yoshida, K
通讯作者：
Yoshida, K