Distribution of febrile seizure duration and associations with development.
Distribution of febrile seizure duration and associations with development.
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DOI：
10.1002/ana.22368
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发表时间：
2011-07
影响因子：
11.2
通讯作者：
Shinnar, Shlomo
中科院分区：
文献类型：
--
作者：
Hesdorffer, Dale C.;Benn, Emma K. T.;Bagiella, Emilia;Nordli, Douglas;Pellock, John;Hinton, Veronica;Shinnar, Shlomo
在先前对热性惊厥(FS)的研究中，在缺乏经验证据的情况下，延长FS被定义为持续10或15分钟或更长。我们评估了首次出现FS的队列中FS持续时间的分布，以及FS持续时间与儿童基线特征之间的关系。我们计算了观察到的FS持续至少t分钟的累积概率S(T)=EXP(−t/τ)。数据也用两个指数分布之和的模型[S(T)=αExp(−t/τ1)+(1-α)Exp(−t/τ2)]进行拟合。在评估最佳拟合度后，确定了定义长FS的界限。Logsitic回归被用来检验长FS与基线特征、行为和发育之间的关联。在158名首次出现FS的儿童中，中位持续时间为4.0分钟。FS持续时间符合二组分混合指数模型。使用该模型，我们确定了一个种群，占FS的82.3%，平均持续时间为3.8分钟(短FS)，以及第二个种群，占FS的17.7%，平均持续时间为39.8分钟(长FS)。长FS与发育延迟(p=0.010)、延迟和初次FS年龄较小(p=0.048)显著相关。与儿童无热性惊厥持续时间的分布一样，首次惊厥发作持续时间的分布可以通过假设两个总体来最好地模拟。发育迟缓和年龄较小与FS延长有关。我们的数据进一步支持将10分钟定义为简单FS的上限。
In prior studies of febrile seizures (FS), prolonged FS are defined, absent empirical evidence, as lasting 10 or 15 minutes or more. We assessed the distribution of FS duration in a cohort with first FS, and the association between FS duration and baseline characteristics of the children. We calculated the observed cumulative probability, S(t), that a FS would last at least t minutes, S(t) = exp(−t/ τ) . Data were also fit using a model obtained as the sum of two exponential distributions [S(t) = αexp(−t/τ1)+(1-α)exp(−t/τ2)]. After assessing the best fit, the cut off defining long FS was determined. Logisitic regression was used to examine associations between long FS and baseline characteristics, behavior and development. In 158 children with a first FS, median duration was 4.0 minutes. Duration of FS was best fit by a two-component mixture exponential model. Using this model we identified one population that accounts for 82.3% of FS and has a mean duration of 3.8 minutes (short FS) and a second population that accounts for 17.7% of FS and has a mean duration of 39.8 minutes (long FS). Long FS were significantly associated with developmental delay (p=0.010) and delays and younger age at first FS (p=0.048). Like the distribution of afebrile seizure duration in children, the distribution of first FS duration is best modeled by assuming two populations. Developmental delay and younger age are associated with prolonged FS. Our data lend further support to defining 10 minutes as the upper limit for a simple FS.
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影响因子：
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