The elusive nature and function of mesenchymal stem cells.

The elusive nature and function of mesenchymal stem cells.
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DOI:
10.1038/nrm3049
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发表时间:
2011-02
期刊:
Nature reviews. Molecular cell biology
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其他
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间充质干细胞(MSC)是存在于许多成体组织基质部分中的多能前体细胞的多样化亚群,引起了转化和基础研究人员的强烈兴趣。间充质干细胞在操作上被定义为其在体外扩增后分化为成骨细胞、脂肪细胞和软骨细胞的能力。然而,它们在体内的同一性、异质性、解剖定位和在成体组织稳态中的功能作用仍然是个谜,并且才刚刚开始被揭示。
Mesenchymal stem cells (MSCs) are a diverse subset of multipotent precursors present in the stromal fraction of many adult tissues and have drawn intense interest from translational and basic investigators. MSCs have been operationally defined by their ability to differentiate into osteoblasts, adipocytes and chondrocytes afterin vitroexpansion. Nevertheless, their identityin vivo, heterogeneity, anatomical localization and functional roles in adult tissue homeostasis have remained enigmatic and are only just starting to be uncovered.
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