Amyloid PET across the cognitive spectrum in former professional and college American football players: findings from the DIAGNOSE CTE Research Project.
Amyloid PET across the cognitive spectrum in former professional and college American football players: findings from the DIAGNOSE CTE Research Project.
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DOI：
10.1186/s13195-023-01315-5
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发表时间：
2023-10-05
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
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Exposure to repetitive head impacts (RHI) in American football players can lead to cognitive impairment and dementia due to neurodegenerative disease, particularly chronic traumatic encephalopathy (CTE). The pathognomonic lesion of CTE consists of perivascular aggregates of hyper-phosphorylated tau in neurons at the depths of cortical sulci. However, it is unclear whether exposure to RHI accelerates amyloid-β (Aβ) plaque formation and increases the risk for Alzheimer’s disease (AD). Although the Aβ neuritic plaques characteristic of AD are observed in a minority of later-stage CTE cases, diffuse plaques are more common. This study examined whether former professional and college American football players, including those with cognitive impairment and dementia, have elevated neuritic Aβ plaque density, as measured by florbetapir PET. Regardless of cognitive and functional status, elevated levels of florbetapir uptake were not expected. We examined 237 men ages 45–74, including 119 former professional (PRO) and 60 former college (COL) football players, with and without cognitive impairment and dementia, and 58 same-age men without a history of contact sports or TBI (unexposed; UE) and who denied cognitive or behavioral symptoms at telephone screening. Former players were categorized into four diagnostic groups: normal cognition, subjective memory impairment, mild cognitive impairment, and dementia. Positive florbetapir PET was defined by cortical-cerebellar average SUVR of ≥ 1.10. Multivariable linear regression and analysis of covariance (ANCOVA) compared florbetapir average SUVR across diagnostic and exposure groups. Multivariable logistic regression compared florbetapir positivity. Race, education, age, and APOE4 were covariates. There were no diagnostic group differences either in florbetapir average SUVR or the proportion of elevated florbetapir uptake. Average SUVR means also did not differ between exposure groups: PRO-COL (p = 0.94, 95% C.I. = [− 0.033, 0.025]), PRO-UE (p = 0.40, 95% C.I. = [− 0.010, 0.029]), COL-UE (p = 0.36, 95% CI = [0.0004, 0.039]). Florbetapir was not significantly associated with years of football exposure, cognition, or daily functioning. Cognitive impairment in former American football players is not associated with PET imaging of neuritic Aβ plaque deposition. These findings are inconsistent with a neuropathological diagnosis of AD in individuals with substantial RHI exposure and have both clinical and medico-legal implications. NCT02798185. The online version contains supplementary material available at 10.1186/s13195-023-01315-5.
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影响因子：
9.9
作者：
Grothe MJ;Barthel H;Sepulcre J;Dyrba M;Sabri O;Teipel SJ;Alzheimer's Disease Neuroimaging Initiative
通讯作者：
Alzheimer's Disease Neuroimaging Initiative
影响因子：
3.2
作者：
Bieniek KF;Cairns NJ;Crary JF;Dickson DW;Folkerth RD;Keene CD;Litvan I;Perl DP;Stein TD;Vonsattel JP;Stewart W;Dams-O'Connor K;Gordon WA;Tripodis Y;Alvarez VE;Mez J;Alosco ML;McKee AC;TBI/CTE Research Group
通讯作者：
TBI/CTE Research Group
DOI：
10.1186/s13195-021-00872-x
发表时间：
2021-08-12
期刊：
Alzheimer's research & therapy
影响因子：
--
作者：
Alosco ML;Mariani ML;Adler CH;Balcer LJ;Bernick C;Au R;Banks SJ;Barr WB;Bouix S;Cantu RC;Coleman MJ;Dodick DW;Farrer LA;Geda YE;Katz DI;Koerte IK;Kowall NW;Lin AP;Marcus DS;Marek KL;McClean MD;McKee AC;Mez J;Palmisano JN;Peskind ER;Tripodis Y;Turner RW 2nd;Wethe JV;Cummings JL;Reiman EM;Shenton ME;Stern RA;DIAGNOSE CTE Research Project Investigators
通讯作者：
DIAGNOSE CTE Research Project Investigators
影响因子：
4.8
作者：
Guskiewicz, KM;Marshall, SW;Jordan, BD
通讯作者：
Jordan, BD
影响因子：
9.9
作者：
Hicks, Amelia J.;Ponsford, Jennie L.;Rowe, Christopher C.
通讯作者：
Rowe, Christopher C.