Proteinaceous determinants of surface colonization in bacteria: bacterial adhesion and biofilm formation from a protein secretion perspective.
Proteinaceous determinants of surface colonization in bacteria: bacterial adhesion and biofilm formation from a protein secretion perspective.
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DOI：
10.3389/fmicb.2013.00303
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发表时间：
2013-10-14
影响因子：
5.2
通讯作者：
Desvaux M
中科院分区：
文献类型：
--
作者：
Chagnot C;Zorgani MA;Astruc T;Desvaux M
生物或非生物表面的细菌定殖由两个完全不同的生理过程引起，即细菌粘附和生物膜形成。广义地说，生物膜被定义为微生物细胞的固着发育。生物膜的形成是在细菌粘附后发生的，但并非所有可逆或不可逆粘附的单个细菌细胞都不可避免地进入固着生长模式。在促进细菌定殖的分子决定簇中，表面蛋白是功能上最多样化的活性组分。然而，要存在于细菌细胞表面，首先必须分泌蛋白质。由于分泌蛋白与其同源分泌系统的密切联系，分泌组（分泌系统及其蛋白底物）是理解蛋白分泌及其相关生理功能的关键概念。蛋白质分泌系统在这里被认为是在双胚层-LPS（原型革兰氏阴性），单胚层（原型革兰氏阳性）和双胚层-霉菌（原型耐酸）细菌之间的细胞包膜结构的差异。此外，参与细菌定殖过程的同源分泌蛋白质也从单一蛋白质到超分子蛋白质结构以及非经典蛋白质分泌。这种最先进的补充分泌组（分泌系统及其同源效应器）参与表面定殖过程中的diderm-LPS和monoderm细菌铺平了道路，为未来的研究方向在该领域。
Bacterial colonization of biotic or abiotic surfaces results from two quite distinct physiological processes, namely bacterial adhesion and biofilm formation. Broadly speaking, a biofilm is defined as the sessile development of microbial cells. Biofilm formation arises following bacterial adhesion but not all single bacterial cells adhering reversibly or irreversibly engage inexorably into a sessile mode of growth. Among molecular determinants promoting bacterial colonization, surface proteins are the most functionally diverse active components. To be present on the bacterial cell surface, though, a protein must be secreted in the first place. Considering the close association of secreted proteins with their cognate secretion systems, the secretome (which refers both to the secretion systems and their protein substrates) is a key concept to apprehend the protein secretion and related physiological functions. The protein secretion systems are here considered in light of the differences in the cell-envelope architecture between diderm-LPS (archetypal Gram-negative), monoderm (archetypal Gram-positive) and diderm-mycolate (archetypal acid-fast) bacteria. Besides, their cognate secreted proteins engaged in the bacterial colonization process are regarded from single protein to supramolecular protein structure as well as the non-classical protein secretion. This state-of-the-art on the complement of the secretome (the secretion systems and their cognate effectors) involved in the surface colonization process in diderm-LPS and monoderm bacteria paves the way for future research directions in the field.
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