Preparation of multilayered polymeric structures using a novel four-needle coaxial electrohydrodynamic device.
Preparation of multilayered polymeric structures using a novel four-needle coaxial electrohydrodynamic device.
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DOI:
10.1002/marc.201300777
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发表时间:
2014-03
影响因子:
4.6
通讯作者:
Edirisinghe, Mohan
中科院分区:
文献类型:
--
作者:
Labbaf, Sheyda;Ghanbar, Hanif;Stride, Eleanor;Edirisinghe, Mohan
Coaxial four-needle electrohydrodynamic forming is applied for the first time to prepare layered structures in both particle and fiber form. Four different biocompatible polymers, polyethylene glycol, poly (lactic-co-glycolic acid), polycaprolactone, and polymethylsilsesquioxane, are used to generate four distinct layers confirmed using transmission and scanning electron microscopy combined with focused ion beam milling. The incorporation and release of different dyes within the polymeric system of four layers are demonstrated, something that is much desired in modern applications such as the polypill where multiple active pharmaceutical ingredients can be combined to treat numerous diseases.
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