Impact of Behavioral Drug Abuse Treatment on Sexual Risk Behaviors: An Integrative Data Analysis of Eight Trials Conducted Within the National Drug Abuse Treatment Clinical Trials Network.
Impact of Behavioral Drug Abuse Treatment on Sexual Risk Behaviors: An Integrative Data Analysis of Eight Trials Conducted Within the National Drug Abuse Treatment Clinical Trials Network.
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DOI：
10.1007/s11121-018-0913-6
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发表时间：
2018-08
期刊：
影响因子：
--
通讯作者：
Sales JM
中科院分区：
文献类型：
--
作者：
Brown JL;Eriksen MD;Gause NK;Brody GH;Sales JM
行为药物滥用治疗对危险性行为的影响程度在很大程度上尚不清楚。这项研究采用综合数据分析方法，研究了行为药物滥用治疗对性危险行为的影响，该方法在国家药物滥用治疗临床试验网络 (CTN) 内进行的八项试验中进行。来自八项随机对照试验的基线时性活跃的参与者 (N = 1,305) 被纳入汇总数据集中； 48.7% 为女性，64.1% 自认为是少数种族/族裔，M (SD) 年龄为 34.9 (9.6)。纵向逻辑回归以指示变量（干预后为 1）、研究条件（对照、干预）及其相互作用作为预测因子，估计了干预后危险性行为（即，不一致使用安全套和/或过去 30 天内超过 1 个性伴侣）的概率；该分析对每项试验都采用了随机效应，并包括相关的控制变量。使用相互作用的线性项和二次项与病情状态合并基于干预后几周的效果随时间变化的差异。大约 84.2% 的人报告基线时有危险的性行为。对照组和干预组在干预后报告危险性行为的可能性分别降低了 18.5 个百分点和 17.3 个百分点。结果表明，在干预后八周（对照）或九周（干预）之前，危险性行为的发生率会降低；危险的性行为随之增加。在干预和对照试验条件下，行为 CTN 试验参与与性危险行为的减少相关。参与行为药物使用治疗可能会带来减少性危险行为的次要好处。
The extent to which behavioral drug abuse treatments affect sexual risk behaviors is largely unknown. This study examined the impact of behavioral drug abuse treatments on sexual risk behaviors using an integrative data analysis approach across eight trials conducted within the National Drug Abuse Treatment Clinical Trials Network (CTN). Participants (N = 1,305) from eight randomized controlled trials who were sexually active at baseline were included in the pooled dataset; 48.7% were female, 64.1% self-identified as a racial/ethnic minority, with M (SD) age of 34.9 (9.6). Longitudinal logistic regression estimated the probability of risky sexual behavior (i.e., inconsistent condom use and/or >1 sexual partner in past 30 days) post-intervention with an indicator variable (1 for post-intervention), study condition (control, intervention), and their interaction as predictors; the analysis employed random effects for each trial and included relevant control variables. Time-varying differences in effects based on weeks post-intervention were incorporated using interacted linear and quadratic terms with condition status. Approximately 84.2% reported risky sexual behaviors at baseline. The control and intervention conditions were 18.5 and 17.3 percentage points less likely to report risky sexual behavior post-intervention, respectively. Results suggest decreasing rates of risky sex engagement until eight weeks (control) or nine weeks (intervention) post-intervention; risky sexual behavior subsequently increased. Behavioral CTN trial participation was associated with decreased sexual risk behaviors in both the intervention and control trial conditions. Participation in behavioral substance use treatment may result in secondary benefits of sexual risk behavior reductions.
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影响因子：
5
作者：
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作者：
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