The Dynamics of Prosthetically Elicited Vestibulo-Ocular Reflex Function Across Frequency and Context in the Rhesus Monkey.
The Dynamics of Prosthetically Elicited Vestibulo-Ocular Reflex Function Across Frequency and Context in the Rhesus Monkey.
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DOI：
10.3389/fnins.2018.00088
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发表时间：
2018
影响因子：
4.3
通讯作者：
Rubinstein JT
中科院分区：
文献类型：
--
作者：
Phillips JO;Ling L;Nowack AL;Phillips CM;Nie K;Rubinstein JT
前庭神经电刺激可能是调节前庭传入输入以恢复损伤或疾病后前庭功能的可行工具。要做到这一点，这样的刺激器必须提供传入输入，可以很容易地被中枢神经系统解释，以准确地代表头部运动来驱动反射行为。由于前庭传入神经具有不同的电敏感性，以及对头部旋转速度和加速度的自然敏感性不同，并且电刺激对多个传入神经产生生理上的同步激活，因此很难先验地确定头部速度和加速度与驱动前庭反射功能的电刺激性质（即双相脉冲速率或脉冲电流幅值）之间的适当转换。为了从经验上探讨前庭假体刺激与前庭反射行为之间转换的本质，我们对恒河猴进行了恒速率和恒幅脉冲序列的脉冲速率和电流幅值，以及脉冲调频（FM）和电流调幅（AM）的正弦调制脉冲序列的调制频率的参数化改变。此外，我们还研究了不同眼位和头位对观察到的眼动反应的影响。我们得出的结论是，调制频率对刺激引起的观察到的眼速度有强烈而独特的影响，从一个管到另一个管。此外，初始眼位和初始头位对观察到的反应有很强的影响。这些是叠加在之前已经展示过的脉冲频率或电流振幅和眼速之间的关系上的。
Electrical vestibular neurostimulation may be a viable tool for modulating vestibular afferent input to restore vestibular function following injury or disease. To do this, such stimulators must provide afferent input that can be readily interpreted by the central nervous system to accurately represent head motion to drive reflexive behavior. Since vestibular afferents have different galvanic sensitivity, and different natural sensitivities to head rotational velocity and acceleration, and electrical stimulation produces aphysiological synchronous activation of multiple afferents, it is difficult to assign a priori an appropriate transformation between head velocity and acceleration and the properties of the electrical stimulus used to drive vestibular reflex function, i.e., biphasic pulse rate or pulse current amplitude. In order to empirically explore the nature of the transformation between vestibular prosthetic stimulation and vestibular reflex behavior, in Rhesus macaque monkeys we parametrically varied the pulse rate and current amplitude of constant rate and current amplitude pulse trains, and the modulation frequency of sinusoidally modulated pulse trains that were pulse frequency modulated (FM) or current amplitude modulated (AM). In addition, we examined the effects of differential eye position and head position on the observed eye movement responses. We conclude that there is a strong and idiosyncratic, from canal to canal, effect of modulation frequency on the observed eye velocities that are elicited by stimulation. In addition, there is a strong effect of initial eye position and initial head position on the observed responses. These are superimposed on the relationships between pulse frequency or current amplitude and eye velocity that have been shown previously.
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影响因子：
2.8
作者：
Dai, Chenkai;Fridman, Gene Y.;Della Santina, Charles C.
通讯作者：
Della Santina, Charles C.
DOI：
10.1097/mao.0000000000000003
发表时间：
2014-01
期刊：
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
影响因子：
--
作者：
Golub JS;Ling L;Nie K;Nowack A;Shepherd SJ;Bierer SM;Jameyson E;Kaneko CR;Phillips JO;Rubinstein JT
通讯作者：
Rubinstein JT
影响因子：
2
作者：
Dai, Chenkai;Fridman, Gene Y.;Chiang, Bryce;Davidovics, Natan S.;Melvin, Thuy-Anh;Cullen, Kathleen E.;Della Santina, Charles C.
通讯作者：
Della Santina, Charles C.
DOI：
10.1007/s10162-010-0208-5
发表时间：
2010-09-01
影响因子：
2.4
作者：
Fridman, Gene Y.;Davidovics, Natan S.;Della Santina, Charles C.
通讯作者：
Della Santina, Charles C.
影响因子：
2.5
作者：
FERNANDEZ, C;BAIRD, RA;GOLDBERG, JM
通讯作者：
GOLDBERG, JM