Effects of vestibular prosthesis electrode implantation and stimulation on hearing in rhesus monkeys.
Effects of vestibular prosthesis electrode implantation and stimulation on hearing in rhesus monkeys.
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DOI：
10.1016/j.heares.2010.12.021
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发表时间：
2011-07
期刊：
影响因子：
2.8
通讯作者：
Della Santina, Charles C.
中科院分区：
文献类型：
--
作者：
Dai, Chenkai;Fridman, Gene Y.;Della Santina, Charles C.
为探讨前庭假体电极植入和激活对恒河猴听力的影响，在4只恒河猴单侧3个半规管（SCC）内植入前庭假体电极前后，分别测定听性脑干反应（ABR）和畸变产物耳声发射（DPOAE）。3个左侧SCC中的每一个均通过经乳突入路植入电极。右耳作为对照，没有手术操作。在植入前（BI）和植入后4周（无电刺激（NS）和有电刺激（S））进行听力测试。在后一种情况下，通过多通道前庭假体的3个电极对中的每一个将编码3个维度的头部角速度的假体电刺激递送到左前庭神经的3个壶腹分支。电刺激包括基线速率为94脉冲/秒的电荷平衡双相脉冲，脉冲频率由头部角速度从48-222脉冲/秒调制。植入耳对1、2和4kHz短声和短音的ABR听阈从BI到NS增加5-10 dB，从NS到S再增加约5dB。右耳未见明显变化。植入耳DPOAE振幅从BI到NS降低2-14 dB。植入耳的DPOAE振幅略有降低，但无显著性差异，而DPOAE/噪声基底比在NS和S之间相应增加。前庭假体电极植入和激活对恒河猴听力的影响虽小但可测量。结合临床观察，人工耳蜗植入患者很少表现出前庭损伤或假性前庭神经刺激的迹象，这些结果表明，尽管多通道前庭假体电极在人体中的植入和激活会带来听力损失的风险，但这种损失不太可能严重。
To investigate the effects of vestibular prosthesis electrode implantation and activation on hearing in rhesus monkeys, we measured auditory brainstem responses (ABR) and distortion product otoacoustic emissions (DPOAE) in four rhesus monkeys before and after unilateral implantation of vestibular prosthesis electrodes in each of 3 left semicircular canals (SCC). Each of the 3 left SCCs were implanted with electrodes via a transmastoid approach. Right ears, which served as controls, were not surgically manipulated. Hearing tests were conducted before implantation (BI) and then 4 weeks post implantation both without electrical stimulation (NS) and with electrical stimulation (S). During the latter condition, prosthetic electrical stimuli encoding 3 dimensions of head angular velocity were delivered to the 3 ampullary branches of the left vestibular nerve via each of 3 electrode pairs of a multichannel vestibular prosthesis. Electrical stimuli comprised charge-balanced biphasic pulses at a baseline rate of 94 pulses/sec, with pulse frequency modulated from 48–222 pulses/s by head angular velocity. ABR hearing thresholds to clicks and tone pips at 1, 2, and 4 kHz increased by 5–10 dB from BI to NS and increased another ~5 dB from NS to S in implanted ears. No significant change was seen in right ears. DPOAE amplitudes decreased by 2–14 dB from BI to NS in implanted ears. There was a slight but insignificant decrease of DPOAE amplitude and a corresponding increase of DPOAE/Noise floor ratio between NS and S in implanted ears. Vestibular prosthesis electrode implantation and activation have small but measurable effects on hearing in rhesus monkeys. Coupled with the clinical observation that patients with cochlear implants only rarely exhibit signs of vestibular injury or spurious vestibular nerve stimulation, these results suggest that although implantation and activation of multichannel vestibular prosthesis electrodes in human will carry a risk of hearing loss, that loss is not likely to be severe.
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DOI：
10.1007/s10162-010-0208-5
发表时间：
2010-09-01
影响因子：
2.4
作者：
Fridman, Gene Y.;Davidovics, Natan S.;Della Santina, Charles C.
通讯作者：
Della Santina, Charles C.
影响因子：
1.8
作者：
HASLWANTER, T
通讯作者：
HASLWANTER, T
DOI：
10.1159/000067572
发表时间：
2002-11-01
期刊：
ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES
影响因子：
--
作者：
Gacek, RR;Gacek, MR
通讯作者：
Gacek, MR
影响因子：
4.6
作者：
Gong, WS;Merfeld, DM
通讯作者：
Merfeld, DM
影响因子：
3.8
作者：
Gong, WS;Merfeld, DM
通讯作者：
Merfeld, DM